ArticleeLife2023
High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex.
Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
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- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
- Inferotemporal face patches are histo-architectonically distinct.Cell reports · 2024Article
- High-resolution awake mouse fMRI at 14 Tesla.bioRxiv : the preprint server for biology · 2024Article
- Fast connectivity gradient approximation: maintaining spatially fine-grained connectivity gradients while reducing computational costs.Communications biology · 2024Article
- The mouse motor system contains multiple premotor areas and partially follows human organizational principles.Cell reports · 2024Article
- The regional variation of laminar thickness in the human isocortex is related to cortical hierarchy and interregional connectivity.PLoS biology · 2023Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Decoding of columnar-level organization across cortical depth using BOLD- and CBV-fMRI at 7 T.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
The characterization of cortical myelination is essential for the study of structure-function relationships in the human brain. However, knowledge about cortical myelination is largely based on post-mortem histology, which generally renders direct comparison to function impossible. The repeating pattern of pale-thin-pale-thick stripes of cytochrome oxidase (CO) activity in the primate secondary visual cortex (V2) is a prominent columnar system, in which histology also indicates different myelination of thin/thick versus pale stripes. We used quantitative magnetic resonance imaging (qMRI) in conjunction with functional magnetic resonance imaging (fMRI) at ultra-high field strength (7 T) to localize and study myelination of stripes in four human participants at sub-millimeter resolution in vivo. Thin and thick stripes were functionally localized by exploiting their sensitivity to color and binocular disparity, respectively. Resulting functional activation maps showed robust stripe patterns in V2 which enabled further comparison of quantitative relaxation parameters between stripe types. Thereby, we found lower longitudinal relaxation rates (
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