ArticleProceedings of the National Academy of Sciences of the United States of America2023
Self-powered, light-controlled, bioresorbable platforms for programmed drug delivery.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Biointegrated Battery-Based Electroceuticals.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Advances and Challenges in Wearable Sensors for Health Monitoring.ACS applied materials & interfaces · 2026Review
- Silicon-Embedded Multifunctional Heterogeneous Integration for Miniaturized Photoplethysmography Detection Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Flexible biodegradable wireless battery-free integrated theranostic adhesive patch.Bioactive materials · 2026Article
- Dynamic and living devices for overcoming fibrosis of implanted biomaterials.Bioengineering & translational medicine · 2026Review
- A programmable bioresorbable electrochemical microneedle sensor array for perioperative monitoring of organ health.Nature biomedical engineering · 2026Article
- Hydrogel-based drug delivery systems for enhanced tumor therapy.RSC advances · 2026Review
- Bioresorbable RFID capsule for assessing medication adherence.Nature communications · 2026Article
- A wireless optogenetic stimulation system for long-term function evaluation of mice forelimb with sub-nerve resolution.Nature communications · 2025Article
- Self-powered green energy-harvesting and sensing interfaces based on hygroscopic gel and water-locking effects.Science advances · 2025Article
- Leaf-based energy harvesting and storage utilizing hygroscopic iron hydrogel for continuous power generation.Nature communications · 2025Article
- Applications of advances in therapeutic electrical stimulation techniques and technologies in precision peripheral nerve repair: a narrative review.Advanced technology in neuroscience · 2025Article
- Article
- Bioresorbable electrodes in implantable electronic healthcare devices.Frontiers in bioengineering and biotechnology · 2025Review
- On-demand drug delivery bioelectronics through a water-processable low dimensional highly conductive MXene layer.Lab on a chip · 2024Article
- A soft implantable energy supply system that integrates wireless charging and biodegradable Zn-ion hybrid supercapacitors.Science advances · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors.
Funding
Abstract
Degradable polymer matrices and porous scaffolds provide powerful mechanisms for passive, sustained release of drugs relevant to the treatment of a broad range of diseases and conditions. Growing interest is in active control of pharmacokinetics tailored to the needs of the patient via programmable engineering platforms that include power sources, delivery mechanisms, communication hardware, and associated electronics, most typically in forms that require surgical extraction after a period of use. Here we report a light-controlled, self-powered technology that bypasses key disadvantages of these systems, in an overall design that is bioresorbable. Programmability relies on the use of an external light source to illuminate an implanted, wavelength-sensitive phototransistor to trigger a short circuit in an electrochemical cell structure that includes a metal gate valve as its anode. Consequent electrochemical corrosion eliminates the gate, thereby opening an underlying reservoir to release a dose of drugs by passive diffusion into surrounding tissue. A wavelength-division multiplexing strategy allows release to be programmed from any one or any arbitrary combination of a collection of reservoirs built into an integrated device. Studies of various bioresorbable electrode materials define the key considerations and guide optimized choices in designs. In vivo demonstrations of programmed release of lidocaine adjacent the sciatic nerves in rat models illustrate the functionality in the context of pain management, an essential aspect of patient care that could benefit from the results presented here.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.