Evidence map›Paper›PMID 36888660›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Structural basis of dual activation of cell division by the actinobacterial transcription factors WhiA and WhiB.

Mirjana Lilic, Neil A Holmes, Matthew J Bush, Alexandra K Marti, David A Widdick, Kim C Findlay, Young Joo Choi, Ruby Froom, Steven Koh, Mark J Buttner and 1 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Overexpression of the Wbl family regulator whiDWorld journal of microbiology & biotechnology · 2025
    Article
  8. Article
  9. ENcyclopedia of TRAnscription Factors in Bacteria and Archaea genomes (ENTRAF) version 2.0.Database : the journal of biological databases and curation · 2025
    Article
  10. Transcription activation inEcoSal Plus · 2024
    Review
  11. WhiB-like proteins: Diversity of structure, function and mechanism.Biochimica et biophysica acta. Molecular cell research · 2024
    Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mirjana LilicLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-2669-3998
Neil A HolmesDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK.ORCID 0000-0002-4979-9680
Matthew J BushDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK.
Alexandra K MartiDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK.ORCID 0000-0003-4711-8957
David A WiddickDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK.
Kim C FindlayDepartment of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK.ORCID 0000-0002-1556-0532
Young Joo ChoiLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Ruby FroomLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Steven KohLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.
Mark J ButtnerDepartment of Molecular Microbiology, John Innes Centre, Norwich NR4 7UH, UK.ORCID 0000-0002-3505-2981
Elizabeth A CampbellLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY 10065.ORCID 0000-0002-1332-128X
John Innes Centre · GBRockefeller University · US

Funding

Structure/function analyses of essential mycobacterial transcription regulatorsR01GM114450 · NIGMS · ROCKEFELLER UNIVERSITY · PI CAMPBELL, ELIZABETH A · 2015 to 2023
$3.4M
Biotechnology and Biological Sciences Research Council BBS/E/J/00000015NIGMS NIH HHS R01 GM114450
6 · The paper itself

Abstract

Studies of transcriptional initiation in different bacterial clades reveal diverse molecular mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both required to express cell division genes in Actinobacteria and are essential in notable pathogens such as

Indexed as

Bacterial ProteinsTranscription FactorsCell DivisionCryoelectron MicroscopyDNA-Directed RNA PolymerasesGene Expression Regulation, BacterialSigma FactorStreptomycesBacterial ProteinsDNA-Directed RNA PolymerasesSigma FactorTranscription Factorscryo-EMRNA polymerasetranscriptionWhiAWhiB

Identifiers

PMID36888660
PMCPMC10243135
OpenAlexW4323532347

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.