Evidence map›Paper›PMID 36884289›Full record

ArticleMolecular biology of the cell2023

The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges.

N Ledoux, W Gauthier-Naud, O Lavoie, V Watters, S Hussein, P Adjibade, R Mazroui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Isoform-Specific Localization Diversifies Human MSI2 Function.bioRxiv : the preprint server for biology · 2026
    Article
  2. The enigma of nuclear FMRP: facts and myths.Frontiers in cell and developmental biology · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

N LedouxCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
W Gauthier-NaudCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
O LavoieCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
V WattersCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
S HusseinCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
P AdjibadeCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
R MazrouiCancer Research Center, Université Laval, Oncology Division, Quebec City, Québec G1R 3S3, Canada.
Université Laval · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fragile-X mental retardation protein (FMRP) is a canonical RNA-binding protein whose absence in humans leads to the development of the fragile-X syndrome, characterized by multiple phenotypes including neurodevelopmental disorders, intellectual disability, autism, and macroorchidism. The primary transcripts of the

Indexed as

Intellectual DisabilityAlternative SplicingDNAFragile X Messenger Ribonucleoprotein 1GenomicsHumansProtein IsoformsDNAFMR1 protein, humanFragile X Messenger Ribonucleoprotein 1Protein Isoforms

Identifiers

PMID36884289
PMCPMC10162414
OpenAlexW4323533060

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.