Evidence map›Paper›PMID 36884135›Full record

ReviewClinical reviews in allergy & immunology2023

Single-Cell Analysis of Patients with Axial Spondyloarthritis After Anti-TNFα Treatment: Experimental Data and Review of the Literature.

Zhi-Bin Zhao, Zhen-Hua Bian, Zhang-Mei Lin, Shu-Fan Wu, Jie Long, Yang Cui, Yang Li, Wende Li, Er-Wei Sun, Zhe-Xiong Lian and 1 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Zhi-Bin Zhao *Medical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Zhen-Hua Bian *School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, China.
Zhang-Mei LinDepartment of Rheumatology and Immunology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Shu-Fan WuDepartment of Rheumatology and Immunology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Jie LongGuangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yang CuiDepartment of Rheumatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Yang LiDepartment of Rheumatology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Wende LiGuangdong Laboratory, Animals Monitoring Institute, Guangdong Key Laboratory of Laboratory Animals, Guangzhou, China.
Er-Wei SunDepartment of Rheumatology and Immunology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China. sunew@smu.edu.cn.
Zhe-Xiong LianGuangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China. zxlian@gdph.org.cn.
Yi HeDepartment of Rheumatology and Immunology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China. heyi1983@smu.edu.cn.
Guangdong Academy of Medical Sciences · CNThird Affiliated Hospital of Southern Medical University · CNGuangdong Laboratory Animals Monitoring Institute · CNSouth China University of Technology · CNSouthern Medical University · CN

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2022A0505050040Guangdong Provincial Platform Base and Science and Technology Infrastructure Construction Project 2021B1212060002National Key Research and Development Program of China 2021YFF0702600
6 · The paper itself

Abstract

Axial spondyloarthritis (Ax-SpA) is a chronic inflammatory disease that predominantly affects the axial joints and is most common in young men. However, the precise immune cell subset involved in Ax-SpA remains unclear. Our study characterized the periphery immune landscape of Ax-SpA patients before and after anti-TNFα treatment using single-cell transcriptomics and proteomics sequencing and elucidated the effects of anti-TNFα treatment at the single-cell level. First, we found that peripheral granulocytes and monocytes significantly increased in Ax-SpA patients. Second, we identified a more functional subtype of regulatory T cells, which was present in synovial fluid and increased in patients after treatment. Third, we identified a cluster of inflammatory monocyte subset with stronger inflammatory and chemotactic characteristics. A potential interaction between classical monocytes and granulocytes via the CXCL8/2-CXCR1/2 signaling pathway was observed, which decreased after treatment. Together, these results defined the complex expression profiles and advanced our understanding of the immune atlas in Ax-SpA patients before and after anti-TNFα treatment.

Indexed as

Axial SpondyloarthritisSpondylitis, AnkylosingHumansJointsMaleMonocytesSingle-Cell AnalysisAnti-TNFα treatmentAxial spondyloarthritisSingle-cell analysis

Identifiers

PMID36884135
OpenAlexW4323532736

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.