Evidence map›Paper›PMID 36884097›Full record

ArticleMikrochimica acta2023

Specific capture and determination of glycoprotein using a hybrid epitopes and monomers-mediated molecular-imprinted polymer enzyme-free electrochemical biosensor.

Jia-Yuan He, Hui-Xian Xu, Qin Li, Qin-Yue Zheng, Chong-Zhi Wang, Lian-Di Zhou, Ling Luo, Qi-Hui Zhang, Chun-Su Yuan

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jia-Yuan HeSchool of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China.
Hui-Xian XuSchool of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China.
Qin LiSchool of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China.
Qin-Yue ZhengChongqing Institute for Food and Drug Control, Chongqing, 401121, China.
Chong-Zhi WangTang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, 60637, USA.
Lian-Di ZhouBasic Medical College, Chongqing Medical University, Chongqing, 400016, China. 102501@cqmu.edu.cn.
Ling LuoChongqing Cancer Institute, Chongqing University Cancer Hospital, Chongqing, 400030, China. ling.luo.cqch@hotmail.com.
Qi-Hui ZhangSchool of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, China. qhzhang@cqu.edu.cn.ORCID http://orcid.org/0000-0001-5226-5762
Chun-Su YuanTang Center for Herbal Medicine Research and Department of Anesthesia & Critical Care, University of Chicago, Chicago, IL, 60637, USA.
Chongqing University · CNUniversity of Chicago · USChongqing Medical University · CNZheJiang Institute For Food and Drug Control · CN

Funding

Fundamental and Frontier Research Project of Chongqing No. cstc2018jcyjAX0661Fundamental and Frontier Research Project of Chongqing No.cstc2019jsyj-yzysbAX0020Fundamental Research Funds for the Central Universities 2022CDJXY-003Fundamental Research Funds for the Central Universities No. 2019CDYGYB027Graduate Research and Innovation Foundation of Chongqing No. CYS18033Graduate Research and Innovation Project of Chongqing, 2022 CYB22041National Natural Science Foundation of China No.81973451the Science and Technology Research Program of Chongqing Municipal Education Commission No. KJZD-K201800103
6 · The paper itself

Abstract

A novel molecular-imprinted polymer (MIP)-based enzyme-free biosensor was created for the selective detection of glycoprotein transferrin (Trf). For this purpose, MIP-based biosensor for Trf was prepared by electrochemical co-polymerization of novel hybrid monomers 3-aminophenylboronic acid (M-APBA) and pyrrole on a glassy carbon electrode (GCE) modified with carboxylated multi-walled carbon nanotubes (cMWCNTs). Hybrid epitopes of Trf (C-terminal fragment and glycan) have been selected as templates. The produced sensor exhibited great selective recognition ability toward Trf under optimal preparation conditions, offering good analytical range (0.125-1.25 μM) with a detection limit of 0.024 μM. The proposed hybrid epitope in combination with hybrid monomer-mediated imprinting strategy was successfully applied to detect Trf in spiked human serum samples, with recoveries and relative standard deviations ranging from 94.7 to 106.0% and 2.64 to 5.32%, respectively. This study provided a reliable protocol for preparing hybrid epitopes and monomers-mediated MIP for the synergistic and effective determination of glycoprotein in complicated biological samples.

Indexed as

Biosensing TechniquesMolecular ImprintingNanotubes, CarbonEpitopesGlycoproteinsHumansPolymersTransferrinEpitopesGlycoproteinsNanotubes, CarbonPolymersTransferrinDifferential-pulse voltammetryElectrochemical sensorEpitope molecular imprintingGlycoproteinMulti-walled carbon nanotubesSurface-modified glassy-carbon electrodeTransferrin

Identifiers

PMID36884097
OpenAlexW4323534741

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.