ArticleClinical research in cardiology : official journal of the German Cardiac Society2023
The DZHK research platform: maximisation of scientific value by enabling access to health data and biological samples collected in cardiovascular clinical studies.
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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
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Who cites it
10 citing papers in PubMed.
- Effect of anti-fibrotic therapy on regression of myocardial fibrosis after TAVI: design and rationale of the Reduce-MFA DZHK25 trial.ESC heart failure · 2026Trial
- Baseline characteristics in the TransitionCHF study: asymptomatic patients with heart failure and reduced ejection fraction.ESC heart failure · 2026Observational
- Rationale and design of the randomized 'early ventricular assist device'-Trial (VAD-DZHK3).ESC heart failure · 2025Article
- The 'Advancing Cardiovascular Risk Identification with Structured Clinical Documentation and Biosignal Derived Phenotypes Synthesis' project: conceptual design, project planning, and first implementation experiences.European heart journal. Digital health · 2025Article
- Biomarkers for predicting atrial fibrillation: An explorative sub-analysis of the randomised SCREEN-AF trial.The European journal of general practice · 2024Article
- The Journey to a FAIR CORE DATA SET for Diabetes Research in Germany.Scientific data · 2024Article
- Bridging Data Models in Health Care With a Novel Intermediate Query Format for Feasibility Queries: Mixed Methods Study.JMIR medical informatics · 2024Article
- Transition from asymptomatic to symptomatic systolic chronic heart failure: rationale and design of TransitionCHF.ESC heart failure · 2024Article
- [FAIR health data in the national and international data space].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2024Article
- Real-time cardiovascular magnetic resonance imaging for non-invasive characterisation of heart failure with preserved ejection fraction: final outcomes of the HFpEF stress trial.Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
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Authors and funding
90 authors.
Julia HoffmannDZHK Main Office, Berlin, Germany.
Sabine HanßDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-9133-8685
Monika KrausInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.ORCID http://orcid.org/0000-0003-4825-8724
Jens SchallerInstitute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Augustenburger Platz 1, Berlin, Germany.ORCID http://orcid.org/0000-0002-9399-1653
Christian SchäferInstitute of Clinical Chemistry and Laboratory Medicine, Matthias Nauck: Spokesman of the Clinical Research Platform of the German Centre for Cardiovascular Research (DZHK), University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-8873-7231
Dana StahlIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-4283-4543
Stefan D AnkerDepartment of Internal Medicine and Cardiology, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID http://orcid.org/0000-0002-0805-8683
Gabriele AntonInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.ORCID http://orcid.org/0000-0003-0483-892X
Thomas BahlsInstitute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-9150-5589
Stefan BlankenbergDepartment of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-6488-2362
Arne BlumentrittIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-6068-0752
Leif-Hendrik BoldtDepartment of Internal Medicine and Cardiology, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Steffen CordesDZHK Main Office, Berlin, Germany.
Steffen DeschHeart Center Leipzig at Leipzig University and Leipzig Heart Science, Leipzig, Germany.ORCID http://orcid.org/0000-0002-1349-9969
Wolfram DoehnerDepartment of Internal Medicine and Cardiology, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID http://orcid.org/0000-0001-7598-708X
Marcus DörrDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-7471-475X
Frank EdelmannDepartment of Internal Medicine and Cardiology, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
Ingo EitelMedical Clinic II Cardiology Angiology Intensive Care Medicine, University Heart Center Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-6442-246X
Matthias EndresCenter for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0001-6520-3720
Stefan EngelhardtInstitute of Pharmacology and Toxicology, Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0001-5378-8661
Jeanette ErdmannInstitute for Cardiogenetics, University Lübeck, Lübeck, Germany.ORCID http://orcid.org/0000-0002-4486-6231
Katharina EulenburgDZHK Main Office, Berlin, Germany.
Volkmar FalkDepartment for Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID http://orcid.org/0000-0002-7911-8620
Stephan B FelixDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-0744-091X
Derk FrankDepartment of Internal Medicine III (Cardiology, Angiology, Critical Care), University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0001-7561-075X
Thomas FrankeDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Norbert FreyKlinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-7611-378X
Tim FriedeDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5347-7441
Lars GeidelIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.
Lisa GermansIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.
Ulrich GrabmaierMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0002-2168-4232
Martin HalleDepartment of Prevention and Sports Medicine, Faculty of Medicine, University Hospital 'Klinikum Rechts Der Isar', Technical University Munich, Munich, Germany.ORCID http://orcid.org/0000-0003-3065-530X
Jörg HausleiterMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0003-2909-7961
Vera JakobiMedizinische Klinik III, Kardiologie, Universitätsklinikum Frankfurt, Frankfurt, Germany.
Ahmad-Fawad JebranHerz- Und Thorax-Chirurgie, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-4281-0960
Alexander JobsHeart Center Leipzig at Leipzig University and Leipzig Heart Science, Leipzig, Germany.ORCID http://orcid.org/0000-0002-9421-8726
Stefan KääbMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0001-8824-3581
Mahir KarakasDepartment of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
Hugo A KatusKlinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2293-2314
Alexandra KlattDZHK Main Office, Berlin, Germany.
Christoph KnosallaDepartment for Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID http://orcid.org/0000-0002-8127-5019
Joachim KrebserDZHK Main Office, Berlin, Germany.ORCID http://orcid.org/0000-0002-3624-4790
Ulf LandmesserMedical Department of Cardiology, Deutsches Herzzentrum der Charité, Berlin, Germany.ORCID http://orcid.org/0000-0002-0214-3203
Mahsa LeeDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-9532-761X
Kristin LehnertDepartment of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-2342-3949
Stephanie LesserDZHK Main Office, Berlin, Germany.ORCID http://orcid.org/0000-0002-8104-6216
Katrin LeyhIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.
Roberto LorbeerDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2224-9208
Stephanie Mach-KolbInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.
Benjamin MederKlinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0741-2633
Eike NagelInstitute for Experimental and Translational Cardiovascular Imaging and DZHK Center for Cardiovascular Imaging, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-6044-950X
Christian H NolteCenter for Stroke Research Berlin, Charité Universitätsmedizin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5577-1775
Abdul S ParwaniDepartment of Internal Medicine and Cardiology, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.ORCID http://orcid.org/0000-0003-2043-7050
Astrid PetersmannInstitute of Clinical Chemistry and Laboratory Medicine, Matthias Nauck: Spokesman of the Clinical Research Platform of the German Centre for Cardiovascular Research (DZHK), University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0001-9843-2263
Miriam PulsClinic of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5540-1264
Henriette RauIndependent Trusted Third Party of the University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-0816-0693
Maximilian ReiserDepartment of Radiology, University Hospital, LMU Munich, Munich, Germany.
Otto RienhoffDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Tabea ScharfeDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0001-9091-1796
Mario SchattschneiderInstitute of Clinical Chemistry and Laboratory Medicine, Matthias Nauck: Spokesman of the Clinical Research Platform of the German Centre for Cardiovascular Research (DZHK), University Medicine Greifswald, Greifswald, Germany.
Heiko ScheelDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Renate B SchnabelDepartment of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7170-9509
Andreas SchusterClinic of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1508-1125
Boris SchmittAbteilung Pädiatrie M.S. Kardiologie, Charité Universitätsmedizin Berlin, Berlin, Germany.
Tim SeidlerClinic of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-6158-5087
Moritz SeiffertDepartment of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0002-3940-9079
Barbara-Elisabeth StähliInstitute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Augustenburger Platz 1, Berlin, Germany.
Adriane StasDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.
Thomas J StockerMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0003-1162-2502
Lukas von StülpnagelMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0003-2238-2815
Holger ThieleHeart Center Leipzig at Leipzig University and Leipzig Heart Science, Leipzig, Germany.ORCID http://orcid.org/0000-0002-0169-998X
Rolf WachterClinic of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-2231-2200
Reza WakiliMedizinische Klinik III, Kardiologie, Universitätsklinikum Frankfurt, Frankfurt, Germany.ORCID http://orcid.org/0000-0002-6326-1537
Tanja WeisKlinik für Kardiologie, Angiologie und Pneumologie, Universitätsklinikum Heidelberg, Heidelberg, Germany.
Kerstin WeitmannInstitute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-0386-283X
Heinz-Erich WichmannInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.ORCID http://orcid.org/0000-0002-1721-3796
Philipp WildPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center Mainz, Mainz, Germany.ORCID http://orcid.org/0000-0003-4413-9752
Tanja ZellerDepartment of Cardiology, University Heart and Vascular Center Hamburg-Eppendorf, Hamburg, Germany.ORCID http://orcid.org/0000-0003-3379-2641
Wolfgang HoffmannInstitute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-6359-8797
Elisabeth Maria ZeisbergDepartment of Cardiology and Pneumology, University Medical Center of Göttingen, Georg-August University, Göttingen, Germany.ORCID http://orcid.org/0000-0001-5184-0497
Wolfram-Hubertus ZimmermannInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0003-1190-4040
Dagmar KreftingDepartment of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-7238-5339
Titus KühneInstitute of Computer-Assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Augustenburger Platz 1, Berlin, Germany.
Annette PetersInstitute of Epidemiology, Helmholtz Zentrum München, Munich, Germany.ORCID http://orcid.org/0000-0001-6645-0985
Gerd HasenfußClinic of Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.ORCID http://orcid.org/0000-0002-5942-361X
Steffen MassbergMedizinische Klinik Und Poliklinik I, Klinikum Der Universität München, LMU München, Munich, Germany.ORCID http://orcid.org/0000-0001-7387-3986
Thomas SommerMax-Delbrück-Centrum Für Molekulare Medizin (MDC), Berlin, Germany.ORCID http://orcid.org/0000-0001-9990-5202
Stefanie DimmelerInstitute of Cardiovascular Regeneration, Universitätsklinikum Frankfurt, Frankfurt/Main, Germany.ORCID http://orcid.org/0000-0002-1045-2436
Thomas EschenhagenDepartment of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.ORCID http://orcid.org/0000-0003-1750-1170
Matthias NauckInstitute of Clinical Chemistry and Laboratory Medicine, Matthias Nauck: Spokesman of the Clinical Research Platform of the German Centre for Cardiovascular Research (DZHK), University Medicine Greifswald, Greifswald, Germany. matthias.nauck@med.uni-greifswald.de.ORCID http://orcid.org/0000-0002-6678-7964
Funding
No grant is acknowledged in the PubMed record.
Abstract
The German Centre for Cardiovascular Research (DZHK) is one of the German Centres for Health Research and aims to conduct early and guideline-relevant studies to develop new therapies and diagnostics that impact the lives of people with cardiovascular disease. Therefore, DZHK members designed a collaboratively organised and integrated research platform connecting all sites and partners. The overarching objectives of the research platform are the standardisation of prospective data and biological sample collections among all studies and the development of a sustainable centrally standardised storage in compliance with general legal regulations and the FAIR principles. The main elements of the DZHK infrastructure are web-based and central units for data management, LIMS, IDMS, and transfer office, embedded in a framework consisting of the DZHK Use and Access Policy, and the Ethics and Data Protection Concept. This framework is characterised by a modular design allowing a high standardisation across all studies. For studies that require even tighter criteria additional quality levels are defined. In addition, the Public Open Data strategy is an important focus of DZHK. The DZHK operates as one legal entity holding all rights of data and biological sample usage, according to the DZHK Use and Access Policy. All DZHK studies collect a basic set of data and biosamples, accompanied by specific clinical and imaging data and biobanking. The DZHK infrastructure was constructed by scientists with the focus on the needs of scientists conducting clinical studies. Through this, the DZHK enables the interdisciplinary and multiple use of data and biological samples by scientists inside and outside the DZHK. So far, 27 DZHK studies recruited well over 11,200 participants suffering from major cardiovascular disorders such as myocardial infarction or heart failure. Currently, data and samples of five DZHK studies of the DZHK Heart Bank can be applied for.
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Biological Specimen BanksHumansProspective StudiesCardiovascular diseaseData and biomaterial collectionGerman Centre for Cardiovascular ResearchResearch platformStandardisation
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