Evidence map›Paper›PMID 36883763›Full record

ArticleJournal of neurophysiology2023

Heterosynaptic long-term potentiation of non-nociceptive synapses requires endocannabinoids, NMDARs, CamKII, and PKCζ.

Avery D Franzen, Riley T Paulsen, Emily J Kabeiseman, Brian D Burrell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurophysiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Avery D FranzenDivision of Basic Biomedical Sciences, Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States.ORCID 0000-0002-6287-4999
Riley T PaulsenDivision of Basic Biomedical Sciences, Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States.
Emily J KabeisemanDivision of Basic Biomedical Sciences, Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States.
Brian D BurrellDivision of Basic Biomedical Sciences, Center for Brain and Behavior Research, Sanford School of Medicine, University of South Dakota, Vermillion, South Dakota, United States.ORCID 0000-0002-2562-6072

Funding

Endovanilloid-Mediated Modulation and its Role in Habituation and SensitizationR01NS092716 · NINDS · UNIVERSITY OF SOUTH DAKOTA · PI BURRELL, BRIAN DONALD · 2016 to 2020
$1.4M
G-RISE University of South DakotaT32GM136503 · NIGMS · UNIVERSITY OF SOUTH DAKOTA · PI BAUGH, LEE, BURRELL, BRIAN DONALD · 2020 to 2024
$1.1M
NIGMS NIH HHS T32 GM136503NIGMS NIH HHS T32GM136503NINDS NIH HHS 1R01NS092716NINDS NIH HHS R01 NS092716
6 · The paper itself

Abstract

Noxious stimuli or injury can trigger long-lasting sensitization to non-nociceptive stimuli (referred to as allodynia in mammals). Long-term potentiation (LTP) of nociceptive synapses has been shown to contribute to nociceptive sensitization (hyperalgesia) and there is even evidence of heterosynaptic spread of LTP contributing to this type of sensitization. This study will focus on how activation of nociceptors elicits heterosynaptic LTP (hetLTP) in non-nociceptive synapses. Previous studies in the medicinal leech (

Indexed as

EndocannabinoidsLong-Term PotentiationAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2HumansMammalsMicePainReceptors, N-Methyl-D-AspartateSynapsesCalcium-Calmodulin-Dependent Protein Kinase Type 2EndocannabinoidsReceptors, N-Methyl-D-AspartatecannabinoidHirudonociceptionpainsynaptic plasticity

Identifiers

PMID36883763
PMCPMC10085563

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.