Evidence map›Paper›PMID 36883723›Full record

ArticleOphthalmic epidemiology2024

Visit Adherence and Visual Acuity in Study of COmparative Treatments for REtinal Vein Occlusion 2 (SCORE2).

Brian L VanderBeek, Yinxi Yu, Neal Oden, Paul VanVeldhuisen, Barbara Blodi, Michael Ip, Ingrid U Scott

Abstract read
In one paragraph

Article in Ophthalmic epidemiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brian L VanderBeekScheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4953-118X
Yinxi YuCenter for Preventative Ophthalmology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Neal OdenThe Emmes Company, LLC, Rockville, Illinois, USA.
Paul VanVeldhuisenThe Emmes Company, LLC, Rockville, Illinois, USA.
Barbara BlodiDepartment of Ophthalmology and Visual Science, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Michael IpDoheny Eye Institute, University of California, Los Angeles, California, USA.
Ingrid U ScottDepartment of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID 0000-0002-3908-7153

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
SCORE2 Comparative Trial (SCT)U10EY023533 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCOTT, INGRID U · 2013 to 2018
$7.4M
SCORE2 Comparative Trial (SCT)U10EY023529 · NEI · THE EMMES COMPANY, LLC · PI VAN VELDHUISEN, PAUL C · 2013 to 2018
$6.8M
The SCORE2 Long-Term Follow-Up (SCORE2 LTF)UG1EY023533 · NEI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SCOTT, INGRID U · 2019 to 2021
$3.7M
SCORE2 Comparative Trial (SCT)U10EY023521 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI BLODI, BARBARA A · 2013 to 2018
$1.8M
NEI NIH HHS P30 EY001583NEI NIH HHS U10 EY023521NEI NIH HHS U10 EY023529NEI NIH HHS U10 EY023533NEI NIH HHS UG1 EY023533
6 · The paper itself

Abstract

purposeWe quantify the association between visit adherence and visual acuity (VA) in retinal vein occlusions (CRVO).

methodsThe SCORE2 protocol included a visit every 4 weeks (every 28-35 days) during the first year. Visit adherence was measured as follows: number of missed visits, average and longest (avg and max days) visit interval, and average and longest (avg and max missed days) and unintended visit interval. Avg and max missed days were categorized as on time (0 days), late (>0-60 days), and very late (>60 days). The primary outcome was a change in the Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity letter score (VALS) between baseline study visit and last attended visit during Year 1, using multivariate linear regression models controlling for numerous demographic and clinical factors.

resultsAfter adjustment, for each visit missed, patients lost 3.0 letters (95% CI: -6.2, 0.2) of vision (

conclusionsVisit adherence is associated with VALS outcomes in CRVO patients.

Indexed as

Macular EdemaRetinal Vein OcclusionAngiogenesis InhibitorsBevacizumabHumansIntravitreal InjectionsRanibizumabReceptors, Vascular Endothelial Growth FactorTomography, Optical CoherenceTreatment OutcomeValsartanVisual AcuityAngiogenesis InhibitorsBevacizumabRanibizumabReceptors, Vascular Endothelial Growth FactorValsartanAdherenceAnti-VEGFmacular edema due to central retinal vein occlusionSCORE2

Identifiers

PMID36883723
PMCPMC10485168

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.