Evidence map›Paper›PMID 36883553›Full record

ArticleeLife2023

Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns.

Simon Grund Sørensen, Amruta Shrikhande, Gustav Alexander Poulsgaard, Mikkel Hovden Christensen, Johanna Bertl, Britt Elmedal Laursen, Eva R Hoffmann, Jakob Skou Pedersen

Open access · goldAbstract read
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Simon Grund SørensenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-5494-9375
Amruta ShrikhandeDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Gustav Alexander PoulsgaardDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Mikkel Hovden ChristensenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Johanna BertlDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Britt Elmedal LaursenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.
Eva R HoffmannDNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
Jakob Skou PedersenDepartment of Molecular Medicine (MOMA), Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-7236-4001
Aarhus University · DKUniversity of Copenhagen · DK

Funding

Cancer Research UK C23210/A7574
6 · The paper itself

Abstract

DNA repair deficiencies in cancers may result in characteristic mutational patterns, as exemplified by deficiency of

Indexed as

DNA Repair-Deficiency DisordersNeoplasmsBRCA1 ProteinBRCA2 ProteinDNA HelicasesDNA RepairHumansMaleMutationNuclear ProteinsTranscription FactorsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription Factorscancer biologycomputational biologyDNA damage responsehumanmutational signaturespersonalised medicinepredictive modellingrepair deficiencysystems biology

Identifiers

PMID36883553
PMCPMC10115443
OpenAlexW4323532511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.