Evidence map›Paper›PMID 36883479›Full record

ArticleCirculation2023

Nitrative Modification of Caveolin-3: A Novel Mechanism of Cardiac Insulin Resistance and a Potential Therapeutic Target Against Ischemic Heart Failure in Prediabetic Animals.

Zhijun Meng, Zhen Zhang, Jianli Zhao, Caihong Liu, Peng Yao, Ling Zhang, Dina Xie, Wayne Bond Lau, Jumpei Tsukuda, Theodore A Christopher and 9 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Role of Caveolae and Caveolin in Vascular Physiology and Pathology.Journal of the American Heart Association · 2026
    Review
  7. Article
  8. Article
  9. [Nitrosative stress promotes the malignant biological behavior of breast cancer through the glycolytic pathway].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  10. Article
  11. Article
  12. Role of membrane microdomains in cardiac protection: strategies for diabetic cardiomyopathy.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Caveolae: Metabolic Platforms at the Crossroads of Health and Disease.International journal of molecular sciences · 2025
    Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Zhijun MengDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Zhen ZhangDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Jianli ZhaoDepartment of Biomedical Engineering, the University of Alabama at Birmingham (J.Z., Y.W.).ORCID 0000-0003-4662-2940
Caihong LiuDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Peng YaoDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).ORCID 0000-0002-6996-6167
Ling ZhangDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Dina XieDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Wayne Bond LauDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).ORCID 0000-0002-8064-8290
Jumpei TsukudaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Theodore A ChristopherDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Bernard LopezDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Di ZhuDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Demin LiuDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).ORCID 0000-0002-8784-1026
John Ry ZhangDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).
Erhe GaoCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (E.G., W.K.).
Harry IschiropoulosChildren's Hospital of Philadelphia Research Institute, Philadelphia, PA (H.I.).ORCID 0000-0001-8284-5098
Walter KochCenter for Translational Medicine, Lewis Katz School of Medicine at Temple University, Philadelphia, PA (E.G., W.K.).ORCID 0000-0002-8522-530X
Xinliang MaDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).ORCID 0000-0002-9041-0876
Yajing WangDepartment of Emergency Medicine, Thomas Jefferson University, Philadelphia, PA (Z.M., Z.Z., C.L., P.Y., L.Z., D.X., W.B.L., J.T., T.A.C., B.L., D.Z., D.L., J.R.Z., X.M., Y.W.).ORCID 0000-0002-6358-6948
Hi-Z Technology (United States) · USTemple University · USUniversity of Alabama at Birmingham · USChildren's Hospital of Philadelphia · USShanxi Medical University · CNThomas Jefferson University · US

Funding

Targeting Adiponectin for Cardioprotection in the Ischemic HeartR01HL096686 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG, WANG, YAJING · 2010 to 2024
$4.7M
Cav-3 in Diabetic Myocardial Injury Following Ischemia/ReperfusionR01HL123404 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG · 2015 to 2023
$2.7M
Dysregulated Adiponectin Transmembrane Signaling in Diabetic CoronaryVascular Injury and Heart FailureR01HL157495 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2022 to 2025
$2.3M
Critical Role of Small Extracellular Vesicles in Diabetic Coronary VascularDysfunction and Diabetic Ischemic Heart Failure effortsR01HL158612 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WANG, YAJING · 2021 to 2024
$1.5M
Cav-3 in Diabetic Myocardial Injury Following Ischemia/ReperfusionR56HL123404 · NHLBI · THOMAS JEFFERSON UNIVERSITY · PI MA, XIN-LIANG · 2014 to 2014
$388k
NHLBI NIH HHS R01 HL096686NHLBI NIH HHS R01 HL123404NHLBI NIH HHS R01 HL157495NHLBI NIH HHS R01 HL158612NHLBI NIH HHS R56 HL123404
6 · The paper itself

Abstract

backgroundMyocardial insulin resistance is a hallmark of diabetic cardiac injury. However, the underlying molecular mechanisms remain unclear. Recent studies demonstrate that the diabetic heart is resistant to other cardioprotective interventions, including adiponectin and preconditioning. The "universal" resistance to multiple therapeutic interventions suggests impairment of the requisite molecule(s) involved in broad prosurvival signaling cascades. Cav (Caveolin) is a scaffolding protein coordinating transmembrane signaling transduction. However, the role of Cav3 in diabetic impairment of cardiac protective signaling and diabetic ischemic heart failure is unknown.

methodsWild-type and gene-manipulated mice were fed a normal diet or high-fat diet for 2 to 12 weeks and subjected to myocardial ischemia and reperfusion. Insulin cardioprotection was determined.

resultsCompared with the normal diet group, the cardioprotective effect of insulin was significantly blunted as early as 4 weeks of high-fat diet feeding (prediabetes), a time point where expression levels of insulin-signaling molecules remained unchanged. However, Cav3/insulin receptor-β complex formation was significantly reduced. Among multiple posttranslational modifications altering protein/protein interaction, Cav3 (not insulin receptor-β) tyrosine nitration is prominent in the prediabetic heart. Treatment of cardiomyocytes with 5-amino-3-(4-morpholinyl)-1,2,3-oxadiazolium chloride reduced the signalsome complex and blocked insulin transmembrane signaling. Mass spectrometry identified Tyr

conclusionsNitration of Cav3 at Tyr

Indexed as

Heart FailureInsulin ResistanceMyocardial Reperfusion InjuryPrediabetic StateAdiponectinAnimalsCaveolin 3ChloridesMiceMyocytes, CardiacAdiponectinCaveolin 3Chloridescaveolin 3diabetes mellitusprotein processing, posttranslationalreperfusion injury

Identifiers

PMID36883479
PMCPMC10085855
OpenAlexW4323533736

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.