Evidence map›Paper›PMID 36883013›Full record

ArticleParasitology2023

Comparative transcriptomics from intestinal cells of permissive and non-permissive hosts during

Andrea Langeland, Emilia Grill, Amol C Shetty, Damien M O'Halloran, John M Hawdon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasitology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea LangelandDepartment of Biological Sciences, The George Washington University, Washington DC, USA.ORCID 0000-0001-5132-6420
Emilia GrillDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington DC, USA.
Amol C ShettyInstitue for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Damien M O'HalloranDepartment of Biological Sciences, The George Washington University, Washington DC, USA.
John M HawdonDepartment of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington DC, USA.

Funding

Identification and validation of mutations causing naturally occurring multi-drug resistance in hookwormR21AI137771 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI HAWDON, JOHN M, O'HALLORAN, DAMIEN M · 2018 to 2019
$439k
NIAID NIH HHS R21 AI137771
6 · The paper itself

Abstract

Soil-transmitted nematodes (STNs) place a tremendous burden on health and economics worldwide with an estimate of at least 1.5 billion people, or 24% of the population, being infected with at least 1 STN globally. Children and pregnant women carry the heavier pathological burden, and disease caused by the blood-feeding worm in the intestine can result in anaemia and delays in physical and intellectual development. These parasites are capable of infecting and reproducing in various host species, but what determines host specificity remains unanswered. Identifying the molecular determinants of host specificity would provide a crucial breakthrough towards understanding the biology of parasitism and could provide attractive targets for intervention. To investigate specificity mechanisms, members of the hookworm genus

Indexed as

AncylostomiasisHookworm InfectionsAncylostomaAnimalsCricetinaeFemaleHost SpecificityHumansIntestinesMicePregnancyTranscriptomeAncylostoma ceylanicumdifferential expressionhookwormhost specificityrodents

Identifiers

PMID36883013
PMCPMC10192101

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.