Evidence map›Paper›PMID 36883000›Full record

ArticleESC heart failure2023

Acute myocarditis with transient myocardial thickening in two oncologic patients treated with anti-GD2 immunotherapy.

Esther Aurensanz-Clemente, Álex Pérez Casares, Juan Pablo Muñoz, Patricia García-Canadilla, Flavio Zuccarino, Joan Sanchez-de-Toledo

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Esther Aurensanz-ClementePediatric Cardiology Department, Sant Joan de Déu Children Hospital, Barcelona, Spain.ORCID 0000-0002-1521-9553
Álex Pérez CasaresPediatric Cardiology Department, Sant Joan de Déu Children Hospital, Barcelona, Spain.
Juan Pablo MuñozOncology Department, Sant Joan de Déu Children Hospital, Barcelona, Spain.
Patricia García-CanadillaInterdisciplinary Cardiovascular Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Spain.
Flavio ZuccarinoRadiology Department, Hospital del Mar, Barcelona, Spain.
Joan Sanchez-de-ToledoPediatric Cardiology Department, Sant Joan de Déu Children Hospital, Barcelona, Spain.
Hospital Sant Joan de Déu Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immunotherapy has considerably improved clinical outcomes in different types of cancers but has also been associated with the development of myocarditis, especially with that mediated by immune checkpoint inhibitors. To the best of our knowledge, these are the first cases of myocarditis after anti-GD2 immunotherapy reported to date. We present two cases of paediatric patients who, after anti-GD2 infusion, presented severe myocarditis with myocardial hypertrophy detected on echocardiography and confirmed with cardiac magnetic resonance imaging. An increase in myocardial T1 and extracellular volume of up to 30% was observed with heterogeneous intramyocardial late enhancement. Myocarditis after anti-GD2 immunotherapy may be more common than appreciated, occurs early after starting treatment, has a malignant course, and responds to higher steroid doses.

Indexed as

MyocarditisChildEchocardiographyHeartHumansImmunotherapyMyocardiumCardiac magnetic resonance imagingCorticosteroidsImmunotherapyMyocarditis

Identifiers

PMID36883000
PMCPMC10192236
OpenAlexW4323531241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.