Evidence map›Paper›PMID 36882870›Full record

ArticleParasites & vectors2023

Determination of the effect of collars containing 10% w/w imidacloprid and 4.5% w/w flumethrin (Seresto®) on the incidence of Leishmania and other canine vector-borne pathogen infections in Greece.

Panagiota Ligda, Manuela Gizzarelli, Despoina Kostopoulou, Valentina Foglia Manzillo, Anastasios Saratsis, Katerina Saratsi, Susan Michler, Hannah Ringeisen, Annette Boegel, Bettina Schunack and 5 more

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. RedefiningCurrent research in parasitology & vector-borne diseases · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Panagiota Ligda *Veterinary Research Institute, Hellenic Agricultural Organization-Demeter, 57001, Thermi, Thessaloniki, Greece.
Manuela Gizzarelli *Department of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137, Naples, Italy.
Despoina Kostopoulou *Veterinary Research Institute, Hellenic Agricultural Organization-Demeter, 57001, Thermi, Thessaloniki, Greece.
Valentina Foglia ManzilloDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137, Naples, Italy.
Anastasios SaratsisVeterinary Research Institute, Hellenic Agricultural Organization-Demeter, 57001, Thermi, Thessaloniki, Greece.
Katerina SaratsiVeterinary Research Institute, Hellenic Agricultural Organization-Demeter, 57001, Thermi, Thessaloniki, Greece.
Susan MichlerElanco Animal Health, 40789, Monheim, Germany.
Hannah RingeisenElanco Animal Health, 40789, Monheim, Germany.
Annette BoegelElanco Animal Health, 40789, Monheim, Germany.
Bettina SchunackElanco Animal Health, 40789, Monheim, Germany.
Matthias PollmeierElanco Animal Health, 40789, Monheim, Germany.
Michalis KontrafourisVeterinary Centre of Leros, 85400, Platanos, Leros, Greece.
Ourania TsatsakiVet Clinic, Thoukididou 6, 71307, Heraklion, Crete, Greece.
Gaetano OlivaDepartment of Veterinary Medicine and Animal Production, University of Naples Federico II, 80137, Naples, Italy. gaeoliva@unina.it.
Smaragda SotirakiVeterinary Research Institute, Hellenic Agricultural Organization-Demeter, 57001, Thermi, Thessaloniki, Greece. smaro_sotiraki@yahoo.gr.
Forest Research Institute · BGUniversity of Naples Federico II · ITCentre for Research and Technology Hellas · GRStavros Niarchos Foundation · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe objective of this field study was to assess the effect of treating a considerable portion of a dog population naturally exposed to canine vector-borne pathogens (CVBPs) in endemic areas with a 10% w/w imidacloprid/4.5% w/w flumethrin collar (Seresto®) on the transmission of CVBPs and the resulting incidence of infection.

methodsA total of 479 dogs from two sites were enrolled in the study. Collars were placed on all dogs continuously for 21 months, with replacement of the collar every 7 months. All dogs were examined, including body weight and blood/conjunctival swab collections, every 7 months. Serum samples were analysed for the presence of antibodies against Leishmania infantum, Ehrlichia canis and Anaplasma phagocytophilum. PCR assays were also performed on blood samples and conjunctival swab collected from the dogs for the presence of L. infantum, and on blood samples only for the presence of Ehrlichia spp. and Anaplasma spp. Sand flies were collected, identified to species level and molecularly tested for L. infantum throughout two vector activity seasons.

resultsThe results showed that the Seresto collar was safe with continuous use. At study inclusion, 419, 370 and 453 dogs tested negative for L. infantum, Ehrlichia spp. and Anaplasma spp., respectively (353 dogs tested negative for any pathogen). Overall, 90.2% of the dogs were protected from L. infantum infection on both sites combined. The entomological survey confirmed the presence of competent vectors of L. infantum at all monitored locations, namely the sand flies Phlebotomus neglectus and Phlebotomus tobbi, both of which are regarded as the most important competent vectors in the Mediterranean basin. All captured sand flies tested negative for L. infantum. Protection against ticks and fleas was high, with only two dogs showing a low number of ticks and seven dogs having low numbers of fleas at single evaluation time points. Across the entire study population, a number of dogs became infected with tick-transmitted pathogens, but prevention of transmission was 93% for E. canis and 87.2% for Anaplasma spp. when all cases from both sites were combined.

conclusionsThe Seresto

Indexed as

CanidaeLeishmania infantumPhlebotomusPsychodidaeAnaplasmaAnimalsDogsEhrlichiaGreeceHumansIncidenceNeonicotinoidsNitro CompoundsPyrethrinsflumethrinimidaclopridNeonicotinoidsNitro CompoundsPyrethrinsCanine vector-borne pathogensCollarFlumethrinImidaclopridPrevention

Identifiers

PMID36882870
PMCPMC9990277
OpenAlexW4323363167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.