ArticleBMC biology2023
Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves.
Article in BMC biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 20 citations in OpenAlex.
- Coral color morphs exhibit distinct microbial and proteomic profiles linked to stress and immune mechanisms in a changing ocean.Microbiome · 2026Article
- Glass scallop genome reveals key adaptations to deep-sea environments and ectosymbiosis.Nature communications · 2026Article
- Chromosome-level genomes of hard clams Meretrix lamarckii (Deshayes, 1853) and Meretrix meretrix (Linnaeus, 1758).Scientific data · 2026Article
- DOO: integrated multi-omics resources for deep ocean organisms.Nucleic acids research · 2026Article
- EHItk: a toolkit for accessing Earth Hologenome Initiative data resources.Bioinformatics advances · 2026Article
- The chromosomal genome sequence of the buttercup lucine,Wellcome open research · 2026Article
- Genome of the enigmatic watering-pot shell and morphological adaptations for anchoring in sediment.BMC genomics · 2025Article
- Genomic, transcriptomic and epigenomic signatures of ageing and cold adaptation in the Antarctic clamOpen biology · 2025Article
- Chromosome-level genome assembly of the intertidal lucinid clam Indoaustriella scarlatoi.Scientific data · 2025Article
- Degenerated vision, altered lipid metabolism, and expanded chemoreceptor repertoires enable Lindaspio polybranchiata to thrive in deep-sea cold seeps.BMC biology · 2025Article
- Photosymbiosis shaped animal genome architecture and gene evolution as revealed in giant clams.Communications biology · 2025Article
- Horizontal transmission of symbiotic bacteria and host selective sweep in the giant clamISME communications · 2025Article
- Widespread HCD-tRNA derived SINEs in bivalves rely on multiple LINE partners and accumulate in genic regions.Mobile DNA · 2024Article
- Chromosome-level genome assembly and annotation of rare and endangered tropical bivalve, Tridacna crocea.Scientific data · 2024Article
- Scallop-bacteria symbiosis from the deep sea reveals strong genomic coupling in the absence of cellular integration.The ISME journal · 2024Article
- Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves.BMC biology · 2023Article
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Authors and funding
17 authors at 7 institutions in 3 countries.
Funding
Abstract
backgroundBivalves have independently evolved a variety of symbiotic relationships with chemosynthetic bacteria. These relationships range from endo- to extracellular interactions, making them ideal for studies on symbiosis-related evolution. It is still unclear whether there are universal patterns to symbiosis across bivalves. Here, we investigate the hologenome of an extracellular symbiotic thyasirid clam that represents the early stages of symbiosis evolution.
resultsWe present a hologenome of Conchocele bisecta (Bivalvia: Thyasiridae) collected from deep-sea hydrothermal vents with extracellular symbionts, along with related ultrastructural evidence and expression data. Based on ultrastructural and sequencing evidence, only one dominant Thioglobaceae bacteria was densely aggregated in the large bacterial chambers of C. bisecta, and the bacterial genome shows nutritional complementarity and immune interactions with the host. Overall, gene family expansions may contribute to the symbiosis-related phenotypic variations in different bivalves. For instance, convergent expansions of gaseous substrate transport families in the endosymbiotic bivalves are absent in C. bisecta. Compared to endosymbiotic relatives, the thyasirid genome exhibits large-scale expansion in phagocytosis, which may facilitate symbiont digestion and account for extracellular symbiotic phenotypes. We also reveal that distinct immune system evolution, including expansion in lipopolysaccharide scavenging and contraction of IAP (inhibitor of apoptosis protein), may contribute to the different manners of bacterial virulence resistance in C. bisecta.
conclusionsThus, bivalves employ different pathways to adapt to the long-term co-existence with their bacterial symbionts, further highlighting the contribution of stochastic evolution to the independent gain of a symbiotic lifestyle in the lineage.
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