Evidence map›Paper›PMID 36882762›Full record

ArticleMolecular brain2023

Properties of Nav1.8

Akihiro Yamada, Ayaka I Yamada, Jennifer Ling, Hidemasa Furue, Wenqin Luo, Jianguo G Gu

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Skin innervation and itsFrontiers in cellular neuroscience · 2026
    Review
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Akihiro Yamada *Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Ayaka I Yamada *Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Jennifer LingDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Hidemasa FurueDepartment of Neurophysiology, Hyogo Medical University, Nishinomiya, 663-8501, Japan.
Wenqin LuoDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Jianguo G GuDepartment of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA. jianguogu@uabmc.edu.ORCID 0000-0002-8404-9850
University of Alabama at Birmingham · USHyogo University · JPUniversity of Pennsylvania · US

Funding

Mechanisms of Nociception in the Trigeminal SystemR01DE018661 · NIDCR · UNIVERSITY OF FLORIDA · PI JIANGUO GU · 2008 to 2026
$6.9M
Cellular and Ion Channel Mechanisms Underlying the Sense of Light Touch in MammalsR01DE023090 · NIDCR · UNIVERSITY OF CINCINNATI · PI JIANGUO GU · 2013 to 2026
$6.1M
Ion channels and their functions at the node of Ranvier of mammalian somatosensory afferent fibersR01NS109059 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GU, JIANGUO · 2019 to 2023
$2.2M
NIDCR NIH HHS DE018661NIDCR NIH HHS DE023090NIDCR NIH HHS R01 DE018661NIDCR NIH HHS R01 DE023090NINDS NIH HHS R01 NS109059
6 · The paper itself

Abstract

Nav1.8-positive afferent fibers are mostly nociceptors playing a role in mediating thermal and mechanical pain, but mechanoreceptors within these afferents have not been fully investigated. In this study, we generated mice expressing channel rhodopsin 2 (ChR2) in Nav1.8-positive afferents (Nav1.8

Indexed as

RhodopsinTouchAnimalsLightMechanoreceptorsMicePainRhodopsinHigh threshold mechanoreceptors (HTMRs)Hindpaw glabrous skinLow threshold mechanoreceptors (LTMRs)Mechanical painNav1.8OptogeneticsOpto-tagged single-fiber recordingTouch

Identifiers

PMID36882762
PMCPMC9990257
OpenAlexW4323364737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.