ArticleBMC medicine2023
Water intake, hydration status and 2-year changes in cognitive performance: a prospective cohort study.
Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 39 citations in OpenAlex.
- Use of Machine Learning to Identify Determinants of Habitual-Preformed Water Intake.The Journal of nutrition · 2026Trial
- Multimodal MRI local metrics and cognitive performance following water intake in 12-h water-restricted adults: a randomized controlled trial.Frontiers in nutrition · 2026Trial
- Associations of malnutrition and hydration status with cognitive frailty in older adults.European geriatric medicine · 2026Article
- Cognitive Testing in Spanish Older Adults: A Scoping Review.Geriatrics (Basel, Switzerland) · 2026Review
- Mediation role of estimated pulse wave velocity in the association between physical activity and cognitive function.Medicine · 2026Article
- A Systematic Review of Multimodal Frameworks for Assessing Health Vulnerability in Academicians Across Ergonomic, Lifestyle, and Dietary Domains.Healthcare (Basel, Switzerland) · 2026Review
- Dietary Behavior and Risk of Depression: Effects of Ultra-Processed Food and Water Intake in a National Sample of the United States.Journal of clinical medicine research · 2026Article
- Hydration Knowledge, Water Consumption, and Attitudes Toward Drinking Water Quality Among Adults in Romania: A Cross-Sectional Study.Nutrients · 2026Article
- Association of repeated high serum osmolarity with cognitive function in older Japanese adults in a KOBE study subanalysis.Scientific reports · 2025Article
- Hydration Status of Elite Youth Soccer Players: Training Versus FIFA Competition.Life (Basel, Switzerland) · 2025Article
- Water and wisdom: Hydration as a defence against dementia.Experimental physiology · 2025Article
- Cognitive functions in schizophrenia: the interplay between blood viscosity, serum osmolarity, and symptom severity.BMC psychiatry · 2025Article
- Predicting dementia in people with Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Water intake, hydration status and cognitive functions in older adults - a pilot study.European journal of nutrition · 2025Article
- Exploring the relationship between larmor-frequency electrical conductivity, diffusivity, and tissue volume in the aging brain.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Hydration and health at ages 40-70 years in Salzburg Austria is associated with a median total water intake over 40 mL/kg including at least 1 L/d plain drinking water.Frontiers in public health · 2025Article
- Effect of fluid intake on cognitive function in older individuals: A prospective study.PloS one · 2025Article
- Cross-sectional association between plasma aldosterone concentration and cognitive performance by mini-mental state examination in community dwellers.Frontiers in nutrition · 2025Article
- Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.American journal of translational research · 2025Article
Corrections and comments
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Authors and funding
26 authors at 16 institutions in 2 countries.
Funding
Abstract
backgroundWater intake and hydration status have been suggested to impact cognition; however, longitudinal evidence is limited and often inconsistent. This study aimed to longitudinally assess the association between hydration status and water intake based on current recommendations, with changes in cognition in an older Spanish population at high cardiovascular disease risk.
methodsA prospective analysis was conducted of a cohort of 1957 adults (aged 55-75) with overweight/obesity (BMI between ≥ 27 and < 40 kg/m
resultsThe mean baseline daily total water intake was 2871 ± 676 mL/day (2889 ± 677 mL/day in men; 2854 ± 674 mL/day in women), and 80.2% of participants met the ESFA reference values for an adequate intake. Serum osmolarity (mean 298 ± 24 mmol/L, range 263 to 347 mmol/L) indicated that 56% of participants were physiologically dehydrated. Lower physiological hydration status (i.e., greater serum osmolarity) was associated with a greater decline in global cognitive function z-score over a 2-year period (β: - 0.010; 95% CI - 0.017 to - 0.004, p-value = 0.002). No significant associations were observed between water intake from beverages and/or foods with 2-year changes in global cognitive function.
conclusionsReduced physiological hydration status was associated with greater reductions in global cognitive function over a 2-year period in older adults with metabolic syndrome and overweight or obesity. Future research assessing the impact of hydration on cognitive performance over a longer duration is needed.
trial registrationInternational Standard Randomized Controlled Trial Registry, ISRCTN89898870. Retrospectively registered on 24 July 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.