Evidence map›Paper›PMID 36882675›Full record

ArticleBioprocess and biosystems engineering2023

Efficient bio-production of glutaric acid by a metabolically engineered Escherichia coli LQ-1 based on a novel nitrogen source feeding strategy.

Wenwen Bi, Chen Chen, Tiantian Wang, Pan Ye, Naiqiang Li

Abstract read
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In one paragraph

Article in Bioprocess and biosystems engineering, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenwen BiCollege of Biological Science and Medical Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 201620, People's Republic of China.
Chen ChenCollege of Biological Science and Medical Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 201620, People's Republic of China.
Tiantian WangCollege of Biological Science and Medical Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 201620, People's Republic of China.
Pan YeCollege of Biological Science and Medical Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 201620, People's Republic of China.
Naiqiang LiCollege of Biological Science and Medical Engineering, Innovation Center for Textile Science and Technology, Donghua University, Shanghai, 201620, People's Republic of China. lnq@dhu.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC2106204
6 · The paper itself

Abstract

As an important five-carbon platform chemical to synthesize polyesters and polyamides, glutaric acid is widely used in numerous biochemical fields such as consumer goods, textile, and footwear industries. However, the application of glutaric acid is limited by the low yield of its bio-production. In this study, a metabolically engineered Escherichia coli LQ-1 based on 5-aminovalerate (AMV) pathway was used for glutaric acid fed-batch fermentation. Given the significance of nitrogen source in the bio-production of glutaric acid by AMV pathway, a novel nitrogen source feeding strategy feedbacked by real-time physiological parameters was proposed after evaluating the effects of nitrogen source feeding (such as ammonia and ammonium sulfate) on glutaric acid bio-production. Under the proposed nitrogen source feeding strategy, a significantly improved glutaric acid production of 53.7 g L

Indexed as

Escherichia coliNitrogenFermentationGlutaratesMetabolic EngineeringGlutaratesglutaric acidNitrogenEfficient bio-productionEscherichia coliGlutaric acidNitrogen source feeding strategiesPhysiological parameters feedback

Identifiers

PMID36882675

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.