ArticleScientific reports2023
Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Biological mechanisms of atropine in myopia control (Review).Molecular medicine reports · 2026Pooled it
- Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.Japanese journal of ophthalmology · 2026Review
- Anatomical and Transcriptional Alterations in the Mouse Choroid Induced by All-Trans Retinoic Acid.Investigative ophthalmology & visual science · 2026Article
- The Therapeutic Use of Natural Products in Myopia Prevention: Recent Applications.Molecular nutrition & food research · 2026Review
- Polyamine-Related Gene Families Identification and Regulatory Effects on Early Somatic Embryogenesis via Modulating Gene Expressions and Hormone Levels inPlants (Basel, Switzerland) · 2026Article
- The choroidal macrophage polarization significantly influences myopia development in murine models.iScience · 2026Article
- IMI-2025 Digest.Investigative ophthalmology & visual science · 2025Article
- An Evidence-Based Narrative Review of Scleral Hypoxia Theory in Myopia: From Mechanisms to Treatments.International journal of molecular sciences · 2025Review
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Establishment of an in vitro choroid complex system for vascular response screening.Scientific reports · 2024Article
- Myopia Is an Ischemic Eye Condition: A Review from the Perspective of Choroidal Blood Flow.Journal of clinical medicine · 2024Review
- Topical Application of Bunazosin Hydrochloride Suppresses Myopia Progression With an Increase in Choroidal Blood Perfusion.Investigative ophthalmology & visual science · 2023Article
- Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina.Scientific reports · 2023Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myopia is becoming more common across the world, necessitating the development of preventive methods. We investigated the activity of early growth response 1 (EGR-1) protein and discovered that Ginkgo biloba extracts (GBEs) activated EGR-1 in vitro. In vivo, C57BL/6 J mice were fed either normal or 0.0667% GBEs (200 mg/kg) mixed chow (n = 6 each), and myopia was induced with - 30 diopter (D) lenses from 3 to 6 weeks of age. Refraction and axial length were measured by an infrared photorefractor and an SD-OCT system, respectively. In lens-induced myopia mice, oral GBEs significantly improved refractive errors (- 9.92 ± 1.53 D vs. - 1.67 ± 3.51 D, p < 0.001) and axial elongation (0.22 ± 0.02 mm vs. 0.19 ± 0.02 mm, p < 0.05). To confirm the mechanism of GBEs in preventing myopia progression, the 3-week-old mice were divided into normally fed with either myopic-induced or non-myopic-induced groups and GBEs fed with either myopic-induced or non-myopic-induced groups (n = 10 each). Choroidal blood perfusion was measured with optical coherence tomography angiography (OCTA). In both non-myopic induced groups, compared to normal chow, oral GBEs significantly improved choroidal blood perfusion (8.48 ± 15.75%Area vs. 21.74 ± 10.54%Area, p < 0.05) and expression of Egr-1 and endothelial nitric oxide synthase (eNOS) in the choroid. In both myopic-induced groups, compared to normal chow, oral GBEs also improved choroidal blood perfusion (- 9.82 ± 9.47%Area vs. 2.29 ± 11.84%Area, p < 0.05) and was positively correlated with the change in choroidal thickness. These findings suggest that GBEs may inhibit the progression of myopia by improving choroidal blood perfusion.
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