ArticleScientific reports2023
Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06149078 (The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis), which is not on this map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- From regeneration to immunomodulation: a 20-year global bibliometric analysis of platelet-rich plasma for osteoarthritis.Frontiers in medicine · 2026Pooled it
- Comparison of responders and nonresponders with knee osteoarthritis after transcranial direct current stimulation.Pain management · 2024Trial
- Multiomics insights into the effects of prebiotics on physical function and metabolism in adults with obesity and knee osteoarthritis.Gut microbes · 2026Article
- DNAJB12 mediates the causal effect of obesity on knee osteoarthritis: A mendelian randomization study.Osteoarthritis and cartilage open · 2026Article
- Vitexin Alleviates Knee Osteoarthritis-Associated Cartilage Damage Associated with F3 Modulation.Genes · 2026Article
- Knee Osteoarthritis and Metabolic Disorders: Practical Aspects from Primary Healthcare.Journal of clinical medicine · 2026Article
- [Osteoarthritis: epidemiology, pathophysiology, and conservative treatment options].Innere Medizin (Heidelberg, Germany) · 2026Review
- Does physical activity reduce cardiovascular risk associated with knee osteoarthritis in type 2 diabetes? A nationwide cohort study.The Korean journal of internal medicine · 2026Article
- Practice Patterns in Body Mass Index Optimization Among US Arthroplasty Surgeons: Results of a National American Association of Hip and Knee Surgeons Survey.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Prevalence, functional impact, and associated factors of knee osteoarthritis and knee pain among adults in Urumqi, Northwest China: a community-based cross-sectional study.Frontiers in public health · 2026Article
- Osteoarthritis as a systemic disorder: multi-organ crosstalk in pathogenesis and therapeutic targeting.Frontiers in immunology · 2026Review
- Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: anFrontiers in bioengineering and biotechnology · 2026Article
- Genicular Artery Embolization for Symptomatic Knee Osteoarthritis: A Comprehensive Review of Techniques and Clinical Outcomes.Cardiovascular and interventional radiology · 2025Review
- Association between Osteoarthritis and the Triglyceride-Glucose Index in the Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Construction of a comprehensive protein-protein interaction network to identify key genes associated with osteoarthritis.Medicine · 2025Article
- Volumetric Bone Mineral Density Assessed by Dual-Energy CT Predicts Bone Strength Suitability for Cementless Total Knee Arthroplasty.Medicina (Kaunas, Lithuania) · 2025Article
- Does osteoarthritis physiotherapy research in South Korea align with the National Institute for Health and Care Excellence guidelines: a systematic review of English and Korean literature.BMC rheumatology · 2025Article
- Risk of knee osteoarthritis in patients with multiple atopic conditions: a nationwide study.Scientific reports · 2025Article
- Association of weight-adjusted waist index with all-cause and cardiovascular mortality in individuals with osteoarthritis.BMC musculoskeletal disorders · 2025Article
- Liposome-Based Interventions in Knee Osteoarthritis.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we aimed to evaluate the association between general and central obesity, and their changes with risk of knee osteoarthritis (OA) using retrospective cohort data collected from the Korean National Health Insurance Service. We studied 1,139,463 people aged 50 and over who received a health examination in 2009. To evaluate the association between general and/or central obesity and knee OA risk, a Cox proportional hazard models were used. Additionally, we investigate knee OA risk according to the change in obesity status over 2 years for subjects who had undergone health examinations for 2 consecutive years. General obesity without central obesity (HR 1.281, 95% CI 1.270-1.292) and central obesity without general obesity (HR 1.167, 95% CI 1.150-1.184) were associated with increased knee OA risk than the comparison group. Individuals with both general with central obesity had the highest risk (HR 1.418, 95% CI 1.406-1.429). This association was more pronounced in women and younger age group. Remarkably, the remission of general or central obesity over two years was associated with decreased knee OA risk (HR 0.884; 95% CI 0.867-0.902; HR 0.900; 95% CI 0.884-0.916, respectively). The present study found that both general and central obesity were associated with increased risk of knee OA and the risk was highest when the two types of obesity were accompanied. Changes in obesity status have been confirmed to alter the risk of knee OA.
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