SynthesisScientific reports2023
The lack of keratinized mucosa as a risk factor for peri-implantitis: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Keratinized Mucosa Width and Incidence of Peri-Implant Diseases: A Systematic Review With Meta-Analysis.Journal of periodontal research · 2026Pooled it
- The clinical benefit of alveolar ridge preservation in the posterior maxilla: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- The relationship between adequate keratinized mucosa and peri-implant disease: a systematic review and meta-analysis.BMC oral health · 2025Pooled it
- The clinical efficacy of the allogenic demineralized dentin matrix graft for implant placement: a systematic review.Oral and maxillofacial surgery · 2024Pooled it
- Peri-Implant Tissue Health and Prosthodontic Outcomes of a Cylindrical-Conical Implant with a Progressive Thread Design at Five-Year Follow-Up: A Single-Center Cross-Sectional Retrospective Study.Dentistry journal · 2026Article
- Mesial-Distal Patterns of Alveolar Bone Loss in Periodontitis and Peri-Implantitis: A Comparative Radiographic Study.Dentistry journal · 2026Article
- Dual-Function Antimicrobial Peptides as a Prospective Strategy Against Peri-Implantitis: Bridging Cutaneous Wound Healing and the Peri-Implant Soft-Tissue Seal.Medicina (Kaunas, Lithuania) · 2026Review
- Biomarker-Guided Implant Maintenance (BGIM): A Narrative Review and Protocol Proposal.Journal of clinical medicine · 2026Review
- Shallow vestibular depth as a risk indicator for peri-implantitis: a retrospective analysis of 336 implants.Clinical oral investigations · 2026Review
- Prospective Clinical Evaluation of Customized Titanium Occlusive Barriers with Window Modification for Guided Bone Regeneration: Radiographic and Histological Outcomes.Biomimetics (Basel, Switzerland) · 2026Article
- Two-Step Palatal Shield Technique Using Flowable Composite Resin for Donor-Site Protection Following De-Epithelialized Free Gingival Grafting: A Case Report Illustrating a Novel Technique.Case reports in dentistry · 2026Article
- Long-term outcomes and risk assessment of immediate implants at molar extraction sites in a Taiwan population.Scientific reports · 2025Article
- Article
- New Technique of Double-Layer Alveolar Ridge Preservation Using Collagen Matrix on Periodontally Collapsed Extraction Region: Proof-of-Concept Case Study.Journal of clinical medicine · 2025Article
- Comparing Medium to Long-Term Esthetic, Clinical, and Patient-Reported Outcomes Between Freehand and Computer-Assisted Dental Implant Placement: A Cross-Sectional Study.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Article
- Association of Peri-Implant Mucosa Dimensions With Emergence Profile Angles of the Implant Prosthesis.Clinical and experimental dental research · 2024Article
- Influencing Factors Regarding the Severity of Peri-Implantitis and Peri-Implant Mucositis.Diagnostics (Basel, Switzerland) · 2024Article
- The Significance of Keratinized Mucosa in Implant Therapy: Narrative Literature Review and Case Report Presentation.Journal of clinical medicine · 2024Article
- Review
- Role of immune dysregulation in peri-implantitis.Frontiers in immunology · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to investigate the effect of the lack of keratinized mucosa on the risk of peri-implantitis, while also accounting for possible confounding factors. A literature search was conducted in PubMed and Scopus, including human studies that assessed the presence and width of keratinized mucosa in relation to the occurrence of peri-implantitis. Twenty-two articles were included, and 16 cross-sectional studies we meta-analyzed. The prevalence of peri-implantitis was 6.68-62.3% on patient-level and 4.5-58.1% on implant-level. The overall analysis indicated that the lack of keratinized mucosa was associated with a higher prevalence of peri-implantitis (OR = 2.78, 95% CI 2.07-3.74, p < 0.00001). Similar results were shown when subgroup analyses were performed, including studies with a similar case definition of peri-implantitis (Marginal Bone Loss, MBL ≥ 2 mm) (OR = 1.96, 95% CI 1.41-2.73, p < 0.0001), fixed prostheses only (OR = 2.82, 95% CI 1.85-4.28, p < 0.00001), patients under regular implant maintenance (OR = 2.08, 95% CI 1.41-3.08, p = 0.0002), and studies adjusting for other variables (OR = 3.68, 95% CI 2.32-5.82, p = 0.007). Thus, the lack of keratinized mucosa is a risk factor that increases the prevalence of peri-implantitis and should be accounted for when placing dental implants.
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