Observational studyScientific reports2023
Ligamentum flavum analysis in patients with lumbar discus hernia and lumbar spinal stenosis.
Observational study in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 7 citations in OpenAlex.
- Integrated molecular, microRNA, and biochemical profiling reveals oxidative stress-driven degeneration of the ligamentum flavum in lumbar spinal stenosis.Scientific reports · 2026Article
- Prevalence and Demographic Associations of Ligamentum Flavum Hypertrophy in Lumbar Spinal Stenosis.Orthopedic research and reviews · 2026Article
- Integrated bioinformatic analysis of biomarkers, pathways, and immune cell infiltration in ossification of the ligamentum flavum.International journal of clinical and experimental pathology · 2026Article
- Early Clinical and Radiologic Evaluation of Endoscopic Unilateral Laminectomy for Bilateral Decompression in Degenerative Lumbar Spinal Stenosis: A Retrospective Study.International journal of spine surgery · 2025Article
- Inflammatory Biomarkers in Smokers: Implications for Ligamentum Flavum Hypertrophy.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Efficacy analysis of ligamentum flavum preservation technique under unilateral biportal endoscopic in the treatment of lumbar disc herniation.Frontiers in surgery · 2025Article
- Lumbar Spinal Stenosis: Pathophysiology, Biomechanics, and Innovations in Diagnosis and Management.Journal of spine research and surgery · 2025Article
- MRI machine learning model predicts nerve root sedimentation in lumbar stenosis: a prospective study.Frontiers in neurology · 2025Article
- Exploring Variations in Lumbar Canal Width: An MRI Study on Asymptomatic Patients by Age and Gender.Journal of clinical medicine · 2024Article
- The 3-Steps Approach for Lumbar Stenosis with Anatomical Insights, Tailored for Young Spine Surgeons.Journal of personalized medicine · 2024Article
- MRI parameters predict central lumbar spinal stenosis combined with redundant nerve roots: a prospective MRI study.Frontiers in neurology · 2024Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The normal ligamentum flavum (LF) is a well-defined elastic structure with specific innervation. Several studies investigated LF in patients with lumbar spinal stenosis (LSS) and used lumbar discus hernia (LDH) patients as control group, only on the presumed thesis that LF in this patients have normal morphology. In patients with LSS thickening of the LF is the main cause of stenosis, which is most often presented with neurogenic claudication, whose pathophysiological mechanism is not completely understood. We conducted observational cohort study of 60 operated patients divided into two groups. The first group of 30 patients underwent micro-discectomy (LSH group), and second group with 30 patients underwent decompression, after which analysis of harvested LF was performed. Patients from the LDH group and LSS group differed significantly in the frequencies of chief complaints, duration of symptoms, physical examination, and specific morphological/radiological parameters. The LF analysis showed that the groups differed significantly in the amount of collagen and elastic fibers, as well as in the histological appearance/architectonics of elastic fibers. Also, groups differ in the presence of LF nerve fibers. Our findings speak in favor of the recently postulated inflammatory theory in the origin of spinal neurogenic claudication's.
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