Evidence map›Paper›PMID 36882454›Full record

ArticleScientific reports2023

Real-world data on the incidence and risk of Guillain-Barré syndrome following SARS-CoV-2 vaccination: a prospective surveillance study.

Jongmok Ha, Suyeon Park, Hyunwook Kang, Taeeun Kyung, Namoh Kim, Dong Kyu Kim, Hyeonjoon Kim, Kihoon Bae, Min Cheol Song, Kwang June Lee and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Jongmok Ha *Infectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Suyeon Park *Department of Biostatistics, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Hyunwook KangInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Taeeun KyungInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Namoh KimInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Dong Kyu KimInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Hyeonjoon KimInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Kihoon BaeInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Min Cheol SongInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Kwang June LeeInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Euiho LeeInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea.
Beom Seuk HwangDepartment of Applied Statistics, Chung-Ang University, Seoul, Republic of Korea.
Jinyoung YounDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro Gangnam-Gu, Seoul, 06351, Korea. genian@skku.edu.
Jin Myoung SeokDepartment of Neurology, Soonchunhyang University Hospital Cheonan, Soonchunhyang University College of Medicine, Cheonan, Korea. seok.jm@gmail.com.
Kunhee ParkInfectious Disease Control Center, Gyeonggi Provincial Government, Suwon, Korea. kpark.ghealth@gmail.com.
Government of the Republic of Korea · KRChung-Ang University · KRSamsung Medical Center · KRSoonchunhyang University · KRSoonchunhyang University Hospital Seoul · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence suggests an association between SARS-CoV-2 vaccines and Guillain-Barré syndrome (GBS). Nevertheless, little is understood about the contributing risk factors and clinical characteristics of GBS post SARS-CoV-2 vaccination. In this prospective surveillance study of 38,828,691 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, 55 cases of GBS were reported post vaccination. We estimated the incidence rate of GBS per million doses and the incidence rate ratio for the vaccine dose, mechanism, age, and sex. Additionally, we compared the clinical characteristics of GBS following mRNA-based and viral vector-based vaccinations. The overall incidence of GBS following SARS-CoV-2 vaccination was 1.42 per million doses. Viral vector-based vaccines were associated with a higher risk of GBS. Men were more likely to develop GBS than women. The third dose of vaccine was associated with a lower risk of developing GBS. Classic sensorimotor and pure motor subtypes were the predominant clinical subtypes, and demyelinating type was the predominant electrodiagnostic subtype. The initial dose of viral-vector based vaccine and later doses of mRNA-based vaccine were associated with GBS, respectively. GBS following SARS-CoV-2 vaccination may not be clinically distinct. However, physicians should pay close attention to the classic presentation of GBS in men receiving an initial dose of viral vector-based SARS-CoV-2 vaccines.

Indexed as

COVID-19Guillain-Barre SyndromeViral VaccinesCOVID-19 VaccinesFemaleHumansIncidenceMaleProspective StudiesRNA, MessengerSARS-CoV-2VaccinationCOVID-19 VaccinesRNA, MessengerViral Vaccines

Identifiers

PMID36882454
PMCPMC9989583
OpenAlexW4323359735

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.