Evidence map›Paper›PMID 36882396›Full record

ArticleCell death discovery2023

ACSL1-induced ferroptosis and platinum resistance in ovarian cancer by increasing FSP1 N-myristylation and stability.

Qingyu Zhang, Ning Li, Limei Deng, Xingmei Jiang, Yuming Zhang, Leo Tsz On Lee, Haitao Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death discovery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Qingyu Zhang *Laboratory of Obstetrics and Gynecology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, China. zqy0401@163.com.ORCID http://orcid.org/0000-0002-5284-6257
Ning Li *The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China.ORCID http://orcid.org/0000-0002-0775-9453
Limei DengThe Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China.ORCID http://orcid.org/0000-0002-0670-4231
Xingmei JiangThe Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China.
Yuming ZhangDepartment of Hematology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, China.
Leo Tsz On LeeCancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau, China. LTOLee@um.edu.mo.ORCID http://orcid.org/0000-0003-3691-478X
Haitao ZhangThe Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang, 524023, China. taohaizhang33@163.com.
Guangdong Medical College · CNUniversity of Macau · MO

Funding

Macau University of Science and Technology Foundation (MUST Foundation) 0016/2020/A1Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2021A1515011621Natural Science Foundation of Guangdong Province (Guangdong Natural Science Foundation) 2022A1515012240Universidade de Macau (University of Macau) MYRG2022-00240-FHS
6 · The paper itself

Abstract

Reprogramming of lipid metabolism, which modulates energy utilization and cell signaling, maintains cell survival and promotes cancer metastasis in cancer cells. Ferroptosis is a type of cell necrosis caused by an overload of lipid oxidation, which has been demonstrated to be involved in cancer cell metastasis. However, the mechanism by which fatty acid metabolism regulates the anti-ferroptosis signaling pathways is not fully understood. The formation of ovarian cancer spheroids helps to counteract the hostile microenvironment of the peritoneal cavity with low oxygen, shortage of nutrients, and subjected to platinum therapy. Previously, we demonstrated that Acyl-CoA synthetase long-chain family member 1 (ACSL1) promotes cell survival and peritoneal metastases in ovarian cancer, but the mechanism is still not well elucidated. In this study, we demonstrate that the formation of spheroids and under exposure to platinum chemotherapy increased the levels of anti-ferroptosis proteins as well as ACSL1. Inhibition of ferroptosis can enhance spheroid formation and vice versa. Genetic manipulation of ACSL1 expression showed that ACSL1 reduced the level of lipid oxidation and increased the resistance to cell ferroptosis. Mechanistically, ACSL1 increased the N-myristoylation of ferroptosis suppressor 1 (FSP1), resulting in the inhibition of its degradation and translocation to the cell membrane. The increase in myristoylated FSP1 functionally counteracted oxidative stress-induced cell ferroptosis. Clinical data also suggested that ACSL1 protein was positively correlated with FSP1 and negatively correlated with the ferroptosis markers 4-HNE and PTGS2. In conclusion, this study demonstrated that ACSL1 enhances antioxidant capacity and increases ferroptosis resistance by modulating the myristoylation of FSP1.

Identifiers

PMID36882396
PMCPMC9992462
OpenAlexW4323349275

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.