ArticleCMAJ open
Endometriosis and cardiovascular disease: a population-based cohort study.
Article in CMAJ open. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.Annals of medicine · 2026Pooled it
- Risk of cardiovascular disease and mortality among women with endometriosis: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2026Pooled it
- Pooled it
- Routine Dysmenorrhea Screening in Adolescents: Recommendations for Timely Diagnosis and Treatment of Endometriosis.Journal of pediatrics. Clinical practice · 2026Article
- Association between endometriosis and cardiovascular disease: a population-based cohort study.Journal of global health · 2026Article
- Incidence and factors associated with premature ovarian insufficiency: a population-based cohort study.Human reproduction (Oxford, England) · 2026Article
- Association Between Endometriosis and Cardiovascular Disease: Insights From the UK Biobank.Journal of the American Heart Association · 2026Article
- Bioactive factors in endometriosis peritoneal fluid remodel human cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2026Article
- Risk of congenital anomalies among infants of patients with endometriosis: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Relationship between endometriosis diagnosis, staging, and typology and inflammatory cytokines.F&S reports · 2026Article
- TCF21 promotes epithelial-to-mesenchymal transition and cytoskeleton reorganization in uterine development and endometriosis.Nature communications · 2026Article
- Endometriosis During Peri-Menopause and Post-Menopause: A Review of the Literature.Journal of clinical medicine · 2025Review
- Tailoring cardiovascular risk prediction to females.The Journal of endocrinology · 2025Review
- Aspirin does not modify cardiovascular event risk in endometriosis in the California Teachers Study.European heart journal open · 2025Article
- Article
- Endometriosis and Mortality Risk in US Women: Findings From NHANES 1999-2006.International journal of women's health · 2025Article
- Association Between Atherogenic Index of Plasma and Endometriosis: Evidence from NHANES 1999-2006.International journal of women's health · 2025Article
- Association between endometriosis and arthritis: results from NHANES 1999-2006, genetic correlation analysis, and Mendelian randomization study.Frontiers in immunology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundEndometriosis, a prevalent condition among females of reproductive age, may be associated with increased risk of cardiovascular disease (CVD) through chronic inflammation and early menopause. The objective of this study was to estimate the association between endometriosis and subsequent risk of CVD.
methodsWe conducted a population-based cohort study using administrative health data from Ontario residents from 1993 to 2015. We compared the incidence of CVD and cardiovascular health outcomes between females with endometriosis and 2 age-matched females without endometriosis. The primary outcome was hospital admission for CVD. Secondary outcomes included in-hospital CVD events of interest and emergency department visits for CVD. We used Cox proportional hazards models to estimate adjusted hazard ratios (HRs) between endometriosis and CVD events.
resultsWe identified 166 835 eligible patients with endometriosis and matched 333 706 patients without endometriosis. The mean age of those with endometriosis was 36.4 years. Patients with endometriosis had a higher incidence of hospital admission for CVD (195 admissions/100 000 person-years) compared with those without endometriosis (163 admissions/100 000 person-years). Similarly, the incidence of secondary CVD events was slightly higher among patients with endometriosis (292 cases/100 000 person-years) than among those without endometriosis (224 cases/100 000 person-years). Females with endometriosis had an increased risk of hospital admission (adjusted HR 1.14, 95% confidence interval [CI] 1.10-1.19) and secondary CVD events (adjusted HR 1.26, 95% CI 1.23-1.30).
interpretationIn this large, population-based study, endometriosis was associated with a small increased risk of CVD events. Future studies need to investigate potential etiological mechanisms and strategies to decrease long-term CVD risk in patients with endometriosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.