ArticleEuropean heart journal2023
Circulating ketone bodies and cardiovascular outcomes: the MESA study.
Article in European heart journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Continuously elevated plasma ketone bodies are linked to adverse outcomes in patients with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Inflammatory and catabolic activity mediate the association of plasma β-hydroxybutyrate and mortality in heart failure.ESC heart failure · 2026Observational
- Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.Immunological reviews · 2026Review
- Defects in auxiliary fuel oxidation and mitochondrial pyruvate transport mark transition to overt heart failure in Tgαq*44 mice.Journal of translational medicine · 2026Article
- Circulating Ketone Bodies and Incident Cardiovascular Outcomes and Mortality: Insights From the UK Biobank.Journal of the American Heart Association · 2026Article
- Ketone bodies and incident heart failure: 20-year results from the prospective British Regional Heart Study.ESC heart failure · 2026Article
- Integrating ketone bodies in multi-marker risk prediction of incident heart failure in the multi-ethnic study of atherosclerosis.European journal of preventive cardiology · 2026Article
- Ketone bodies and cancer risk in the general population: The prevention of renal and vascular end-stage disease (PREVEND) study.European journal of clinical investigation · 2025Article
- Ketogenic Diet, Serum Ketone Bodies and Risk of End-Stage Renal Disease in Patients With Diabetic Kidney Disease: A Multi-Cohort Study.Journal of diabetes · 2025Article
- Article
- Characteristics of Cardiac Ketone Body Metabolism Throughout the Life Cycle.Cardiovascular therapeutics · 2025Review
- A Novel Metabolomic Aging Clock Predicting Health Outcomes and Its Genetic and Modifiable Factors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- The ketogenic diet does not improve cardiac function and blunts glucose oxidation in ischaemic heart failure.Cardiovascular research · 2024Article
- Towards Metabolomic-Based Precision Approaches for Classifying and Treating Heart Failure.JACC. Basic to translational science · 2024Review
- Sex differences in circulating metabolites across glycemic status and risk of coronary heart disease.medRxiv : the preprint server for health sciences · 2024Article
- A National Study Exploring the Association between Fasting Duration and Mortality among the Elderly.Nutrients · 2024Article
- Association of a Low-Carbohydrate High-Fat Diet With Plasma Lipid Levels and Cardiovascular Risk.JACC. Advances · 2024Article
- Bridging Metabolic-Associated Steatotic Liver Disease and Cardiovascular Risk: A Potential Role for Ketogenesis.Biomedicines · 2024Review
- Offspring of women with hyperemesis gravidarum are more likely to have cardiovascular abnormalities.BMC pregnancy and childbirth · 2024Article
- Circulating ketone bodies and mortality in heart failure: a community cohort study.Frontiers in cardiovascular medicine · 2024Article
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Authors and funding
13 authors at 9 institutions in 2 countries.
Funding
Abstract
aimsKetone bodies (KB) are an important alternative metabolic fuel source for the myocardium. Experimental and human investigations suggest that KB may have protective effects in patients with heart failure. This study aimed to examine the association between KB and cardiovascular outcomes and mortality in an ethnically diverse population free from cardiovascular disease (CVD). METHODS AND
resultsThis analysis included 6796 participants (mean age 62 ± 10 years, 53% women) from the Multi-Ethnic Study of Atherosclerosis. Total KB was measured by nuclear magnetic resonance spectroscopy. Multivariable-adjusted Cox proportional hazard models were used to examine the association of total KB with cardiovascular outcomes. At a mean follow-up of 13.6 years, after adjusting for traditional CVD risk factors, increasing total KB was associated with a higher rate of hard CVD, defined as a composite of myocardial infarction, resuscitated cardiac arrest, stroke, and cardiovascular death, and all CVD (additionally included adjudicated angina) [hazard ratio, HR (95% confidence interval, CI): 1.54 (1.12-2.12) and 1.37 (1.04-1.80) per 10-fold increase in total KB, respectively]. Participants also experienced an 87% (95% CI: 1.17-2.97) increased rate of CVD mortality and an 81% (1.45-2.23) increased rate of all-cause mortality per 10-fold increase in total KB. Moreover, a higher rate of incident heart failure was observed with increasing total KB [1.68 (1.07-2.65), per 10-fold increase in total KB].
conclusionThe study found that elevated endogenous KB in a healthy community-based population is associated with a higher rate of CVD and mortality. Ketone bodies could serve as a potential biomarker for cardiovascular risk assessment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.