ArticleProceedings of the National Academy of Sciences of the United States of America2023
Vertical growth dynamics of biofilms.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Toward Optimizing Microplastic Transport Models through Biofouling Experiments.Environmental science & technology · 2026Article
- Vm-MSI: a Vancomycin-Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Predictive Computational Framework forPathogens (Basel, Switzerland) · 2026Article
- The key role of cheaters in the persistence of cooperation.BMC biology · 2026Article
- Artificial intelligence applications in biofilm research: computational approaches for biofilm analysis and antimicrobial prediction.Frontiers in microbiology · 2026Review
- Higher levels of antibiotic resistance are less competitive: the hidden ecological cost of no-metabolic cost resistance.bioRxiv : the preprint server for biology · 2025Article
- Equations describing semi-confluent cell growth (II) colony formation on a flat surface.European biophysics journal : EBJ · 2025Article
- Biophysical metabolic modeling of complex bacterial colony morphology.Cell systems · 2025Article
- Biofilm vertical growth dynamics are captured by an active fluid framework.Physical biology · 2025Article
- Metabolically driven flows enable exponential growth in macroscopic multicellular yeast.Science advances · 2025Article
- Spatiotemporal development of expanding bacterial colonies driven by emergent mechanical constraints and nutrient gradients.Nature communications · 2025Article
- Spatial population dynamics of bacterial colonies with social antibiotic resistance.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The key role of cheaters in the persistence of cooperation.bioRxiv : the preprint server for biology · 2024Article
- The biophysical basis of bacterial colony growth.Nature physics · 2024Article
- Metabolically-driven flows enable exponential growth in macroscopic multicellular yeast.bioRxiv : the preprint server for biology · 2024Article
- Computer simulation study of nutrient-driven bacterial biofilm stratification.Journal of the Royal Society, Interface · 2024Article
- Spatial structure, chemotaxis and quorum sensing shape bacterial biomass accumulation in complex porous media.Nature communications · 2024Article
- Bacteria evolve macroscopic multicellularity by the genetic assimilation of phenotypically plastic cell clustering.Nature communications · 2023Article
- Mechanobiology as a tool for addressing the genotype-to-phenotype problem in microbiology.Biophysics reviews · 2023Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During the biofilm life cycle, bacteria attach to a surface and then reproduce, forming crowded, growing communities. Many theoretical models of biofilm growth dynamics have been proposed; however, difficulties in accurately measuring biofilm height across relevant time and length scales have prevented testing these models, or their biophysical underpinnings, empirically. Using white light interferometry, we measure the heights of microbial colonies with nanometer precision from inoculation to their final equilibrium height, producing a detailed empirical characterization of vertical growth dynamics. We propose a heuristic model for vertical growth dynamics based on basic biophysical processes inside a biofilm: diffusion and consumption of nutrients and growth and decay of the colony. This model captures the vertical growth dynamics from short to long time scales (10 min to 14 d) of diverse microorganisms, including bacteria and fungi.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.