ArticleJACC. Heart failure2023
Reclassification of Pre-Heart Failure Stages Using Cardiac Biomarkers: The ARIC Study.
Article in JACC. Heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Long-term risk of heart failure in adult cancer survivors: a systematic review and meta-analysis.Heart (British Cardiac Society) · 2024Pooled it
- Association Between the 2022 AHA/ACC/HFSA Heart Failure Staging and Cardiovascular and Kidney Outcomes in Patients With Diabetes and Kidney Disease: A Post Hoc Analysis of the SCORED Randomized Controlled Trial.Circulation. Heart failure · 2026Trial
- Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial.Cardiovascular diabetology · 2025Trial
- Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open-Label, Noninferiority Study (PARASOL Study).Journal of clinical hypertension (Greenwich, Conn.) · 2025Trial
- Relationship between NT-proBNP, echocardiographic abnormalities and functional status in patients with subclinical siabetic cardiomyopathy.Cardiovascular diabetology · 2024Trial
- Natriuretic peptides are integral in reclassifying heart failure stage and risk.Heart and vessels · 2026Article
- Risk stratification of Stage B heart failure with BNP levels of 35-100 pg/mL: development of the PHASE Index from the CHART-2 Study.European heart journal open · 2026Article
- Diagnostic Tests for Stage B Heart Failure.Current cardiology reports · 2026Review
- Preclinical Heart Failure: A Dynamic Trajectory of Progression, Regression, and Risk.Journal of the American Heart Association · 2026Article
- Refined Heart Failure Stages Incorporating Cardiorespiratory Fitness Are Differentially Associated With Heart Failure Risk in the Community.Journal of the American Heart Association · 2026Observational
- Imaging and Cardiac Biomarker Associations With Preclinical Heart Failure Stage B to C Progression.JACC. Advances · 2026Article
- Prognostic value of Short Physical Performance Battery in older patients with Stage B heart failure: a prospective cohort study.BMC geriatrics · 2025Article
- The continuum of prevention and heart failure in cardiovascular medicine: A joint scientific statement from the Heart Failure Society of America and the American Society for Preventive Cardiology.American journal of preventive cardiology · 2025Review
- Heart Failure and Death in Older Adults With Elevated Cardiac Biomarkers But Without Risk Factors: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Article
- Application of the American Heart Association/American College of Cardiology/Heart Failure Society of America Heart Failure Staging Guidelines in Adults With Chronic Kidney Disease.Journal of the American Heart Association · 2025Article
- Prognostic implication of heart failure stage and left ventricular ejection fraction for patients with in-hospital cardiac arrest: a 16-year retrospective cohort study.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Cardiovascular-Kidney-Metabolic Syndrome: A New Paradigm in Clinical Medicine or Going Back to Basics?Journal of clinical medicine · 2025Review
- Myocardial Abnormalities Across the AHA/ACC Stages of Heart Failure in Patients With Diabetes.JACC. Asia · 2024Article
- Emerging Biomarkers in the Laboratory and in Practice: A Novel Approach to Diagnosing Heart Failure in Diabetes.Journal of diabetes science and technology · 2024Review
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Authors and funding
13 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThe recent heart failure (HF) guideline recommends the inclusion of cardiac biomarkers in defining Stage B HF.
objectivesThe authors evaluated the impact of incorporating cardiac biomarkers to reclassify HF in 5,324 participants (mean age: 75.8 years) without prevalent HF enrolled in the ARIC (Atherosclerosis Risk In Communities) study and assessed prognosis of Stage B using cardiac biomarkers.
methodsUsing N-terminal pro-B-type natriuretic peptide (<125 pg/mL or ≥125 pg/mL), high-sensitivity troponin T (<14 ng/L or ≥14 ng/L), and abnormal cardiac structure/function by echocardiography, individuals were classified as Stage A
resultsOverall, 4,326 (81.3%) individuals were classified as Stage B
conclusionsIncorporating biomarkers based on the new HF guideline reclassified approximately 1 in 5 older adults without prevalent HF to Stage B. The routine measurement of biomarkers can help to identify individuals at higher HF risk who may benefit most from HF prevention efforts.
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