Evidence map›Paper›PMID 36881314›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2023

Assessing Rewiring of the Retinal Circuitry by Electroretinogram (ERG) After Inner Retinal Lesion in Adult Zebrafish.

Lindsey M Barrett, Peter C Meighan, Diana M Mitchell, Michael D Varnum, Deborah L Stenkamp

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Lindsey M BarrettDepartment of Biological Sciences, University of Idaho, Moscow, ID, USA.
Peter C MeighanDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Diana M MitchellDepartment of Biological Sciences, University of Idaho, Moscow, ID, USA.
Michael D VarnumDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Deborah L StenkampDepartment of Biological Sciences, University of Idaho, Moscow, ID, USA. dstenkam@uidaho.edu.
University of Idaho · USWashington State University · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Scott A Minnich · 2012 to 2026
$59.8M
UNDERGRADUATE COLLEGE OUTREACH PROGRAMP20RR016454 · NCRR · UNIVERSITY OF IDAHO · PI CHASE, JENNIFER R · 2001 to 2011
$35.3M
Patterning Genes in Retinal DevelopmentR01EY012146 · NEI · UNIVERSITY OF IDAHO · PI Deborah L Stenkamp · 2004 to 2026
$6.7M
Macrophage Determinants of Retinal RegenerationR01EY030467 · NEI · UNIVERSITY OF IDAHO · PI MITCHELL, DIANA · 2020 to 2024
$1.8M
Acquisition of a Dynamic Imaging SystemS10OD018044 · OD · UNIVERSITY OF IDAHO · PI STENKAMP, DEBORAH L · 2014 to 2014
$455k
Ubiquitin-system manipulations to probe and mitigate ethanol damage in neuronsR21AA028106 · NIAAA · WASHINGTON STATE UNIVERSITY · PI VARNUM, MICHAEL D. · 2021 to 2022
$396k
Synapses in Regenerated RetinaR21EY026814 · NEI · UNIVERSITY OF IDAHO · PI STENKAMP, DEBORAH L · 2016 to 2017
$388k
NCRR NIH HHS P20 RR016454NEI NIH HHS R01 EY012146NEI NIH HHS R01 EY030467NEI NIH HHS R21 EY026814NIAAA NIH HHS R21 AA028106NIGMS NIH HHS P20 GM103408NIH HHS S10 OD018044
6 · The paper itself

Abstract

Adult zebrafish respond to retinal injury with a regenerative response that replaces damaged neurons with Müller glia-derived regenerated neurons. The regenerated neurons are functional, appear to make appropriate synaptic connections, and support visually mediated reflexes and more complex behaviors. Curiously, the electrophysiology of damaged, regenerating, and regenerated zebrafish retina has only recently been examined. In our previous work, we demonstrated that electroretinogram (ERG) recordings of damaged zebrafish retina correlate with the extent of the inflicted damage and that the regenerated retina at 80 days post-injury exhibited ERG waveforms consistent with functional visual processing. In this paper we describe the procedure for obtaining and analyzing ERG recordings from adult zebrafish previously subjected to widespread lesions that destroy inner retinal neurons and engage a regenerative response that restores retinal function, in particular the synaptic connections between photoreceptor axon terminals and the dendritic trees of retinal bipolar neurons.

Indexed as

Retinal NeuronsZebrafishAnimalsElectroretinographyNeurogliaRetinaCentral nervous systemElectroretinogramEyeLesionOuabainPhotoreceptorRegenerationRetinaRetinal bipolar neuronZebrafish

Identifiers

PMID36881314
PMCPMC12039960
OpenAlexW4323347278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.