ArticleAnnals of surgical oncology2023
Frailty Assessed by the Clinical Frailty Scale is Associated with Prognosis After Esophagectomy.
Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Frailty as a predictor of postoperative outcomes in older gastroesophageal cancer patients: a systematic review and meta-analysis.BMC geriatrics · 2025Pooled it
- Improved operative mortality after esophagectomy in patients aged ≥ 75 years over a decade: a nationwide Japanese retrospective cohort study.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Frailty in hepatobiliary and pancreatic (HBP) surgery: a narrative review toward an HBP-specific, implementation-oriented framework.Gland surgery · 2026Review
- Postoperative Complications in Patients with Frailty Syndrome Undergoing Esophagectomy-A Systematic Review with Meta-Analysis.Journal of clinical medicine · 2026Review
- Article
- High prevalence of frailty identified with G8, compared with clinical frailty scale, in older patients with suspected lung cancer.BMC geriatrics · 2026Article
- Pre-radiotherapy frailty and associated determinants in elderly patients with thoracic tumors.Translational cancer research · 2025Article
- A Novel Frailty Index Can Predict the Short-Term Outcomes of Esophagectomy in Older Patients with Esophageal Cancer.Current oncology (Toronto, Ont.) · 2024Article
- Prevalence and Related Factors of Hypokalemia in Patients with Acute Ischemic Stroke.International journal of general medicine · 2024Article
- Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients.World journal of surgery · 2023Article
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Authors and funding
13 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Clinical Frailty Scale (CFS) is a simple and validated tool for assessing frailty, and higher CFS scores are correlated with worse perioperative outcomes after cardiovascular surgery. However, the relationship between the CFS scores and postoperative outcomes after esophagectomy remain unclear.
methodsWe retrospectively analyzed data from 561 patients with esophageal cancer (EC) who underwent resection from August 2010 to August 2020. We defined a CFS score of ≥4 as indicative of frailty; thus, patients were classified into frail patients (CFS scores of ≥4) and non-frail patients (CFS scores of ≤3). The Kaplan-Meier method was used to describe the overall survival (OS) distributions with the log-rank test.
resultsOf the 561 patients, 90 (16%) had frailty and 471 (84%) did not. Frail patients had a significantly older age, lower body mass index, higher American Society of Anesthesiologists physical status classification, and greater cancer progression than non-frail patients. The 5-year survival rate was 68% in non-frail patients and 52% in frail patients. OS was significantly shorter in frail than non-frail patients (p = 0.017 by log-rank test). In particular, OS was significantly shorter in frail patients with clinical stage I-II EC (p = 0.0024 by log-rank test) but was not correlated with frailty in patients with clinical stage III-IV EC (p = 0.87 by log-rank test).
conclusionsPreoperative frailty was associated with shorter OS after resection of EC. The CFS score may be a prognostic biomarker for patients with EC, especially early-stage EC.
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