ArticleJournal of plant research2023
Integrated analysis of metabolome and transcriptome reveals key candidate genes involved in flavonoid biosynthesis in Pinellia ternata under heat stress.
Article in Journal of plant research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed, 22 citations in OpenAlex.
- Article
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- Identification and functional verification of key genes involved in alkaloid biosynthesis inFrontiers in plant science · 2026Article
- Combined transcriptomic and proteomic analyses uncover molecular basis of heat tolerance in pakchoi (Frontiers in plant science · 2026Article
- Responses and adaptations of plants to abiotic stress: transcriptional regulation of secondary metabolic pathways, metabolomics, and nanobiological approaches.Frontiers in genetics · 2026Review
- Analysis of changes and biosynthesis mechanism of flavonoids in Peel of Coffea Arabica L. during ripening based on metabolome and transcriptome.BMC genomics · 2025Article
- Root-Zone Temperature Drives Coordinated Photosynthesis, Root Architecture, and Metabolism Responses inPlants (Basel, Switzerland) · 2025Article
- MsDAD1 acts as a heat-induced "senescence brake" in alfalfa.Frontiers in plant science · 2025Article
- Metabolomic and lipidomic changes in heat-stressed chickpea seeds.Frontiers in plant science · 2025Article
- Comprehensive analysis of PLATZ family genes and their responses to abiotic stresses in Barley.BMC plant biology · 2024Article
- Comparative transcriptomic and metabolomic analyses provide insights into the responses to high temperature stress in Alfalfa (Medicago sativa L.).BMC plant biology · 2024Article
- Integrated transcriptomics and metabolomics provide insights into the biosynthesis of militarine in the cell suspension culture system of Bletilla striata.Advanced biotechnology · 2024Article
- Article
- Integrative Analysis of Metabolomic and Transcriptomic Data Reveals the Mechanism of Color Formation in Corms ofInternational journal of molecular sciences · 2023Article
- Analysis of the response mechanisms ofFrontiers in plant science · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Pinellia ternata (Thunb.) Breit. is an important traditional Chinese medicinal herb and very sensitive to high temperatures. To gain a better understanding of flavonoid biosynthesis under heat stress in P. ternata, we performed integrated analyses of metabolome and transcriptome data. P. ternata plants were subjected to a temperature of 38 °C, and samples were collected after 10 d of treatment. A total of 502 differential accumulated metabolites and 5040 different expressed transcripts were identified, with flavonoid biosynthesis predominantly enriched. Integrated metabolomics and transcriptome analysis showed that high temperature treatment upregulated the expression of CYP73A and downregulated the expression of other genes (such as HCT, CCoAOMT, DFR1, DFR2), which might inhibit the biosynthesis of the downstream metabolome, including such metabolites as chlorogenic acid, pelargonidin, cyanidin, and (-)-epigallocatechin in the flavonoid biosynthesis pathway. The transcription expression levels of these genes were validated by real-time PCR. Our results provide valuable insights into flavonoid composition and accumulation patterns and the candidate genes participating in the flavonoid biosynthesis pathways under heat stress in P. ternata.
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