Evidence map›Paper›PMID 36881190›Full record

ArticlePflugers Archiv : European journal of physiology2023

Ligand sensitivity of type-1 inositol 1,4,5-trisphosphate receptor is enhanced by the D2594K mutation.

Allison Tambeaux, Yuriana Aguilar-Sánchez, Demetrio J Santiago, Madeleine Mascitti, Karyn M DiNovo, Rafael Mejía-Alvarez, Michael Fill, S R Wayne Chen, Josefina Ramos-Franco

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pflugers Archiv : European journal of physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Intracellular CaBiologia futura · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Allison TambeauxDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA.
Yuriana Aguilar-SánchezDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA.
Demetrio J SantiagoDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA.
Madeleine MascittiDepartment of Physiology, Midwestern University, Downers Grove, IL, USA.
Karyn M DiNovoDepartment of Physiology, Midwestern University, Downers Grove, IL, USA.
Rafael Mejía-AlvarezDepartment of Physiology, Midwestern University, Downers Grove, IL, USA.
Michael FillDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA.
S R Wayne ChenDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA.
Josefina Ramos-FrancoDepartment of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, USA. jrfranco@rush.edu.
Rush University Medical Center · USMidwestern University · USSpanish National Centre for Cardiovascular Research · ES

Funding

Limiting Pathological Calcium Induced Calcium Release in HeartR01HL057832 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, GILLESPIE, DIRK · 1997 to 2024
$9.0M
Control of IP3R-Mediated Calcium ReleaseR01GM111397 · NIGMS · RUSH UNIVERSITY MEDICAL CENTER · PI CHEN, SUI RONG WAYNE, FILL, MICHAEL · 2015 to 2018
$1.6M
NHLBI NIH HHS R01 HL057832NIGMS NIH HHS R01 GM111397
6 · The paper itself

Abstract

Inositol 1,4,5-trisphosphate receptor (IP

Indexed as

Calcium SignalingEndoplasmic ReticulumCalciumInositol 1,4,5-Trisphosphate ReceptorsLigandsMutationCalciumInositol 1,4,5-Trisphosphate ReceptorsLigandsCa2+ puffsGain of functionInositol 1,4,5-trisphosphate receptorIP3Single channels

Identifiers

PMID36881190
PMCPMC10105685
OpenAlexW4323348897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.