Evidence map›Paper›PMID 36881147›Full record

ArticleJournal of neurology2023

Profiling cognitive-motor interference in a large sample of persons with progressive multiple sclerosis and impaired processing speed: results from the CogEx study.

R Veldkamp, M D'hooge, B M Sandroff, J DeLuca, D Kos, A Salter, A Feinstein, M P Amato, G Brichetto, J Chataway and 12 more

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03679468 (Improving Cognition in People With Progressive Multiple Sclerosis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03679468 nacompletednot on this map

Improving Cognition in People With Progressive Multiple Sclerosis: A Multi-Arm, Randomized, Blinded, Sham-Controlled Trial of Cognitive Rehabilitation and Aerobic Exercise.

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2019 to 2023Enrolled309ConditionsMultiple Sclerosis, Primary Progressive, Cognitive ImpairmentArmsCognitive Rehabilitation, Sham Exercise, Sham Cognitive Rehabilitation, Aerobic Exercise
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

R VeldkampREVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium. Renee.Veldkamp@uhasselt.be.ORCID http://orcid.org/0000-0002-7317-2431
M D'hoogeREVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.ORCID https://orcid.org/0000-0002-7973-305X
B M SandroffKessler Foundation, East Hanover, NJ, USA.ORCID https://orcid.org/0000-0002-2013-7632
J DeLucaKessler Foundation, East Hanover, NJ, USA.ORCID https://orcid.org/0000-0003-3745-4156
D KosNational MS Center Melsbroek, Steenokkerzeel, Belgium.ORCID https://orcid.org/0000-0003-3566-2269
A SalterDepartment of Neurology, Section on Statistical Planning and Analysis, UT Southwestern Medical Center, Dallas, TX, USA.ORCID https://orcid.org/0000-0002-1088-110X
A FeinsteinDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada.
M P AmatoDepartment NEUROFARBA, Section Neurosciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.ORCID https://orcid.org/0000-0003-3325-3760
G BrichettoScientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Via Operai 40, 16149, Genoa, Italy.
J ChatawayQueen Square MS Centre, Department of Neuroinflammation, University College London (UCL) Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, UK.
R FarrellQueen Square MS Centre, Department of Neuroinflammation, University College London (UCL) Queen Square Institute of Neurology, Faculty of Brain Sciences, UCL, London, UK.
N D ChiaravallotiKessler Foundation, East Hanover, NJ, USA.ORCID https://orcid.org/0000-0003-2943-7567
U DalgasExercise Biology, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000, Aarhus, Denmark.ORCID https://orcid.org/0000-0003-4132-2789
M FilippiNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology Unit, IRCCS, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.ORCID https://orcid.org/0000-0002-5485-0479
J FreemanSchool of Health Professions, Faculty of Health, University of Plymouth, Devon, UK.
R W MotlDepartment of Kinesiology and Nutrition, University of Illinois Chicago, Chicago, IL, USA.ORCID https://orcid.org/0000-0002-5894-2290
C MezaDepartment of Psychiatry, University of Toronto and Sunnybrook Health Sciences Centre, Toronto, ON, M5R 3B6, Canada.
M IngleseDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), and Center of Excellence for Biomedical Research, University of Genoa, Genoa, Italy.
M A RoccaNeuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, and Neurology Unit, IRCCS, San Raffaele Scientific Institute, Via Olgettina 60, 20132, Milan, Italy.ORCID https://orcid.org/0000-0003-2358-4320
G CutterDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, USA.ORCID https://orcid.org/0000-0002-8455-980X
P FeysREVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium.ORCID https://orcid.org/0000-0002-5680-5495
CogEx Research Team

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000448NCI NIH HHS P30 CA091842
6 · The paper itself

Abstract

backgroundPerforming cognitive-motor dual tasks (DTs) may result in reduced walking speed and cognitive performance. The effect in persons with progressive multiple sclerosis (pwPMS) having cognitive dysfunction is unknown.

objectiveTo profile DT-performance during walking in cognitively impaired pwPMS and examine DT-performance by disability level.

methodsSecondary analyses were conducted on baseline data from the CogEx-study. Participants, enrolled with Symbol Digit Modalities Test 1.282 standard deviations below normative value, performed a cognitive single task ([ST], alternating alphabet), motor ST (walking) and DT (both). Outcomes were number of correct answers on the alternating alphabet task, walking speed, and DT-cost (DTC: decline in performance relative to the ST). Outcomes were compared between EDSS subgroups (≤ 4, 4.5-5.5, ≥ 6). Spearman correlations were conducted between the DTC

resultsOverall, participants (n = 307) walked slower and had fewer correct answers on the DT versus ST (both p < 0.001), with a DTC

conclusionDual tasking substantially affects walking performance in cognitively impaired pwPMS, to a similar degree for EDSS subgroups.

Indexed as

Cognitive DysfunctionMultiple SclerosisMultiple Sclerosis, Chronic ProgressiveCognitionGaitHumansProcessing SpeedRetinoidsWalkingRetinoidsCognitive–motor interferenceDual taskGaitMultiple sclerosisProgressive

Identifiers

PMID36881147

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.