ArticleJournal of substance use and addiction treatment2023
Opioid and cannabis co-use: The role of opioid use to cope with negative affect.
Article in Journal of substance use and addiction treatment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Craving for opioid and cannabis use among adults with chronic pain: Insights from a 30-day ecological momentary assessment study.Drug and alcohol dependence · 2025Article
- Chronic pain among primary fentanyl users: The concept of self-medication.European journal of pain (London, England) · 2025Article
- Co-use of opioids and cannabis versus single-substance use: a national analysis of US adults.Frontiers in public health · 2025Article
- Indirect effects of emotion regulation in the relationship between pain and cannabis use in adults 18-64 years.Addictive behaviors · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionThe opioid epidemic is a significant public health concern, particularly among adults with chronic pain. There are high rates of cannabis co-use among these individuals and co-use is related to worse opioid-related outcomes. Yet, little work has examined mechanisms underlying this relationship. In line with affective processing models of substance use, it is possible that those who use multiple substances do so in a maladaptive attempt to cope with psychological distress.
methodWe tested whether, among adults with chronic lower back pain (CLBP), the relation between co-use and more severe opioid-related problems would occur via the serial effects of negative affect (anxiety, depression) and more coping motivated opioid use.
resultsAfter controlling for pain severity and relevant demographics, co-use remained related to more anxiety, depression, and opioid-related problems (but not more opioid use). Further, co-use was indirectly related to more opioid-related problems via the serial effect of negative affect (anxiety, depression) and coping motives. Alternative model testing found co-use was not indirectly related to anxiety or depression via serial effects of opioid problems and coping.
conclusionsResults highlight the important role negative affect may play in opioid problems among individuals with CLBP who co-use opioid and cannabis.
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Registered trials
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