Evidence map›Paper›PMID 36880660›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2023

Ameliorating liver disease in an autosomal recessive polycystic kidney disease mouse model.

Murali K Yanda, Adi Zeidan, Liudmila Cebotaru

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Murali K YandaDepartments of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-4913-470X
Adi ZeidanDepartments of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Liudmila CebotaruDepartments of Medicine and Physiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-4362-8995
Johns Hopkins University · US

Funding

Developing a New Therapeutic Approach for Autosomal Dominant Polycystic Kidney Disease.R01DK125272 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CEBOTARU, LIUDMILA · 2020 to 2024
$1.9M
NIDDK NIH HHS R01 DK125272
6 · The paper itself

Abstract

Systemic and portal hypertension, liver fibrosis, and hepatomegaly are manifestations associated with autosomal recessive polycystic kidney disease (ARPKD), which is caused by malfunctions of fibrocystin/polyductin (FPC). The goal is to understand how liver pathology occurs and to devise therapeutic strategies to treat it. We injected 5-day-old

Indexed as

Polycystic Kidney, Autosomal RecessiveAminopyridinesAnimalsBenzodioxolesCystic Fibrosis Transmembrane Conductance RegulatorHeat-Shock ProteinsHumansLiver CirrhosisMiceReceptors, Cell SurfaceAminopyridinesBenzodioxolesCystic Fibrosis Transmembrane Conductance RegulatorHeat-Shock ProteinslumacaftorPkhd1 protein, mouseReceptors, Cell Surfaceautosomal recessive polycystic kidney diseasebiliary ductscystic fibrosis transmembrane conductance regulatorfibrocystin/polyductinheat shock proteinsprimary cilia

Identifiers

PMID36880660
PMCPMC10085553
OpenAlexW4323348063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.