Evidence map›Paper›PMID 36880344›Full record

Observational studyScandinavian journal of primary health care2023

Agreement between rapid antigen detection test and culture for group A streptococcus in patients recently treated for pharyngotonsillitis - a prospective observational study in primary care.

Karin Rystedt, Katarina Hedin, Mia Tyrstrup, Gunilla Skoog-Ståhlgren, Charlotta Edlund, Christian G Giske, Ronny Gunnarsson, Pär-Daniel Sundvall

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scandinavian journal of primary health care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Karin RystedtResearch, Education, Development & Innovation, Primary Health Care, Region Västra Götaland, Sweden.
Katarina HedinFuturum, Region Jönköping County, and Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
Mia TyrstrupDepartment of Clinical Sciences in Malmö, Family Medicine, Lund University, Malmö, Sweden.
Gunilla Skoog-StåhlgrenUnit for Antibiotics and Infection Control, the Public Health Agency of Sweden, Solna, Sweden.
Charlotta EdlundUnit for Antibiotics and Infection Control, the Public Health Agency of Sweden, Solna, Sweden.
Christian G GiskeDivision of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
Ronny GunnarssonResearch, Education, Development & Innovation, Primary Health Care, Region Västra Götaland, Sweden.
Pär-Daniel SundvallResearch, Education, Development & Innovation, Primary Health Care, Region Västra Götaland, Sweden.
Lund University · SEPublic Health Agency of Sweden · SEUniversity of Gothenburg · SEKarolinska University Hospital · SERegion Västra Götaland · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim was to compare rapid antigen detection test (RADT) and throat culture for group A streptococci (GAS) among patients recently treated with penicillin V for GAS pharyngotonsillitis. DESIGN AND

settingThe study was a secondary analysis within a randomized controlled trial comparing 5 versus 10 days of penicillin V for GAS pharyngotonsillitis. Patients were recruited at 17 primary health care centres in Sweden. SUBJECTS: We included 316 patients ≥ 6 years of age, having 3-4 Centor criteria, a positive RADT and a positive throat culture for GAS at inclusion, and also having a RADT and throat culture for GAS taken at a follow-up visit within 21 days.

main outcome measuresRADT and conventional throat culture for GAS.

resultsThis prospective study showed 91% agreement between RADT and culture at follow-up within 21 days. Only 3/316 participants had negative RADT with a positive throat culture for GAS at follow-up, and 27/316 patients with positive RADT had a negative culture for GAS. Log rank test did not reveal any difference in the decline over time of positive tests between RADT and throat culture (

conclusionRADT and culture for GAS agreed to a high extent also after recent penicillin V treatment. RADT for GAS means a low risk for missing the presence of GAS.KEY POINTSTesting for group A streptococci (GAS) before antibiotic treatment can reduce antibiotic prescription for pharyngotonsillitis. It has been proposed that rapid antigen detection tests (RADT) for group A streptococci after recent penicillin V treatment may be falsely positive due to possible persisting antigens from non-viable bacteria.The decline of the presence of GAS was similar between RADT and conventional throat culture in patients who had recently completed penicillin V treatment for GAS pharyngotonsillitisRADT for GAS is useful in identifying the presence of GAS after recent penicillin V treatment.

Indexed as

PharyngitisStreptococcal InfectionsAnti-Bacterial AgentsHumansInfant, NewbornPenicillin VPrimary Health CareProspective StudiesRandomized Controlled Trials as TopicStreptococcus pyogenesAnti-Bacterial AgentsPenicillin Vprimary carerapid antigen detection testStreptococcal pharyngotonsillitis

Identifiers

PMID36880344
PMCPMC10088972
OpenAlexW4323348417

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.