Evidence map›Paper›PMID 36880311›Full record

ReviewCancer medicine2023

The role of viruses in cancer development versus cancer therapy: An oncological perspective.

Hossein Javid, Alireza Sharbaf Mashhad, Shaghayegh Yazdani, Mahsa Akbari Oryani, Sanaz Akbari, Nastaran Rezagholinejad, Mahboubeh Tajaldini, Mehdi Karimi-Shahri

Open access · goldAbstract readReview
In one paragraph

Review in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Effect ofImmunotherapy · 2025
    Review
  6. Review
  7. Review
  8. Review
  9. Editorial: Cancer in people living with HIV/AIDS.Frontiers in cellular and infection microbiology · 2025
    Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Hossein JavidDepartment of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0002-2248-7708
Alireza Sharbaf MashhadSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Shaghayegh YazdaniSurgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahsa Akbari OryaniDepartment of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sanaz AkbariDepartment of Biology, Islamic Azad University, Mashhad, Iran.ORCID 0000-0003-2548-9431
Nastaran RezagholinejadDepartment of Biochemistry, Payame Noor University (PNU), Mashhad, Iran.
Mahboubeh TajaldiniIschemic Disorder Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Mehdi Karimi-ShahriDepartment of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.ORCID 0000-0003-4910-3134
Mashhad University of Medical Sciences · IRGolestan University · IRIslamic Azad University, Mashhad · IRPayame Noor University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their widespread applications. Virotherapy use lives oncolytic viruses or genetically engineered viruses that selectively infect the tumor cells, replicate, and disrupt the cancerous cells that also induce their anticancer activity by stimulating the host antitumor immune response. Moreover, viruses are widely used as target delivery vectors for specifically delivering different genes, therapeutic agents, and immune-stimulating agents. In addition to having antitumor activity by themselves in combination with conventional therapeutic agents like immune therapy and chemotherapy, Virotherapy agents also elicit promising outcomes. Therefore, in addition to their promising result in monotherapy use, virotherapy agents can also be used in combination with conventional cancer therapy, epigenetic modulators, and even microRNAs without any cross-resistance, which allows the patient not to be deprived of her routine medicine. Still, this combination therapy reduces the adverse effect of the conventional therapies. All together suggest that virotherapy agents as novel potential agents in the field of cancer therapy.

Indexed as

NeoplasmsOncolytic VirotherapyOncolytic VirusesVirusesCombined Modality TherapyHumanscarcinogenoncolytic virusestreatmentvirotherapy

Identifiers

PMID36880311
PMCPMC10242333
OpenAlexW4323347884

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.