Evidence map›Paper›PMID 36880250›Full record

ReviewInternational psychogeriatrics2024

Agitation in cognitive disorders: Progress in the International Psychogeriatric Association consensus clinical and research definition.

Mary Sano, Jeffrey Cummings, Stefanie Auer, Sverre Bergh, Corinne E Fischer, Debby Gerritsen, George Grossberg, Zahinoor Ismail, Krista Lanctôt, Maria I Lapid and 6 more

Abstract readReview
In one paragraph

Review in International psychogeriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Brexpiprazole treatment for agitation in Alzheimer's dementia: A randomized study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Trial
  10. Toward Precision Neuropsychiatry of Dementia: Neuropsychiatric Symptoms as Multidimensional Clinical Phenotypes.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Review
  11. Observational
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Neuropsychiatric symptoms in Alzheimer's disease: Past, present, and future.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mary SanoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, NYC NY and James J. Peters VAMC, Bronx, NY, USA.
Jeffrey CummingsJoy Chambers-Grundy Professor of Brain Science, Director, Chambers-Grundy Center for Transformative Neuroscience, Co-Director, Pam Quirk Brain Health and Biomarker Laboratory, Department of Brain Health, School of Integrated Health Sciences, University of Nevada Las Vegas (UNLV), Las Vegas, NV, USA.ORCID 0000-0001-8944-4158
Stefanie AuerCentre for Dementia Studies, University for Continuing Education Krems, Austria.
Sverre BerghThe Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.
Corinne E FischerFaculty of Medicine, Department of Psychiatry, University of Toronto, Canada.
Debby GerritsenDepartment of Primary and Community Care, Radboud university medical center, Radboud Institute for Health Sciences, Radboud Alzheimer Center, Nijmegen, the Netherlands.
George GrossbergDepartment of Psychiatry & Behavioral Neuroscience, Division of Geriatric Psychiatry, St Louis University School of Medicine, St Louis, MO, USA.
Zahinoor IsmailDepartments Psychiatry, Neurology, Epidemiology, and Pathology, Hotchkiss Brain Institute & O'Brien Institute for Public Health University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-5529-3731
Krista LanctôtHurvitz Brain Sciences Research Program, Sunnybrook Research Institute; and Departments of Psychiatry and Pharmacology/Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Canada.
Maria I LapidDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.
Jacobo MintzerPsychiatrist, Ralph. H. Johnson VA Medical Center, Charleston, SC and Professor, College of Health Professions, Medical University of South Carolina, Charleston, SC, USA.
Rebecca PalmDepartment of Nursing Science, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany.
Paul B RosenbergDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-1106-4299
Michael SplaineOwner Splaine Consulting, Managing Partner, Recruitment Partners LLC.
Kate ZhongDepartment of Brain Health, School of Integrated Health Sciences, University of Nevada, Las Vegas, NV, USA.
Carolyn W ZhuDepartment of Geriatrics and Palliative Medicine, Icahn School of Medicine, NYC, NY and James J. Peters VAMC, Bronx, NY, USA.

Funding

NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's DiseaseR01AG053798 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AISEN, PAUL S., CUMMINGS, JEFFREY L. · 2017 to 2022
$39.4M
Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
Translational and Therapeutics CoreP30AG072959 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI JAGAN AYYAPPAN PILLAI · 2021 to 2026
$23.9M
Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI Robert J. Fox, Jefferson Kinney · 2015 to 2026
$22.8M
Chronic Traumatic Encephalopathy: Detection, Diagnosis, Course, and Risk FactorsU01NS093334 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CUMMINGS, JEFFREY L., REIMAN, ERIC MICHAEL · 2016 to 2022
$17.0M
A Randomized Controlled Trial of Electroconvulsive Therapy plus Usual Care versus Simulated-ECT plus Usual Care for the Acute Management of Severe Agitation in Alzheimer's Dementia (ECT-AD)R01AG061100 · NIA · MCLEAN HOSPITAL · PI FORESTER, BRENT PETER, PETRIDES, GEORGIOS · 2018 to 2023
$9.4M
Pilot trial of dronabinol adjunctive treatment of agitation in Alzheimer's disease (AD)R01AG050515 · NIA · JOHNS HOPKINS UNIVERSITY · PI FORESTER, BRENT PETER, ROSENBERG, PAUL B · 2016 to 2021
$5.5M
Hyperbaric oxygen therapy for cognition in diabetic elderly at high dementia riskR01AG051545 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SANO, MARY, SCHNAIDER BEERI, MICHAL · 2016 to 2021
$3.7M
Circadian rhythm disturbance and agitation in Alzheimer's diseaseR01AG054771 · NIA · JOHNS HOPKINS UNIVERSITY · PI ROSENBERG, PAUL B, WU, MARK N · 2017 to 2021
$3.4M
NVEDARC Clinical CoreP20AG068053 · NIA · CLEVELAND CLINIC FOUNDATION · PI FOX, ROBERT J. · 2020 to 2022
$3.3M
NIA NIH HHS P20 AG068053NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG072959NIA NIH HHS R01 AG050515NIA NIH HHS R01 AG051545NIA NIH HHS R01 AG053798NIA NIH HHS R01 AG054771NIA NIH HHS R01 AG061100NIA NIH HHS R35 AG071476NIA NIH HHS U01 AG016976NIA NIH HHS U24 AG072122NIGMS NIH HHS P20 GM109025NINDS NIH HHS U01 NS093334
6 · The paper itself

Abstract

backgroundThe International Psychogeriatric Association (IPA) published a provisional consensus definition of agitation in cognitive disorders in 2015. As proposed by the original work group, we summarize the use and validation of criteria in order to remove "provisional" from the definition.

methodsThis report summarizes information from the academic literature, research resources, clinical guidelines, expert surveys, and patient and family advocates on the experience of use of the IPA definition. The information was reviewed by a working group of topic experts to create a finalized definition.

resultsWe present a final definition which closely resembles the provisional definition with modifications to address special circumstances. We also summarize the development of tools for diagnosis and assessment of agitation and propose strategies for dissemination and integration into precision diagnosis and agitation interventions.

conclusionThe IPA definition of agitation captures a common and important entity that is recognized by many stakeholders. Dissemination of the definition will permit broader detection and can advance research and best practices for care of patients with agitation.

Indexed as

Cognition DisordersCognitive DysfunctionConsensus Statements as TopicGeriatric PsychiatryHumansPsychomotor AgitationaggressionagitationAlzheimer’s diseaseBehavioral and Psychological Symptoms of DementiadementiaInternational Psychogeriatric Associationneuropsychiatric symptoms

Identifiers

PMID36880250
PMCPMC10684256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.