ArticleJournal of Korean medical science2023
Use of Antibiotics Within the Last 14 Days of Life in Korean Patients: A Nationwide Study.
Article in Journal of Korean medical science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Prevalence and Symptomatic Benefit of Antibiotic Use in End-of-Life Patients in Saudi Arabia: An Observational Cohort Study.Journal of palliative care · 2026Observational
- Single-cell transcriptomics and spatial validation reveal dysfunction of keratinocytes and NK cells driving acne development.Scientific reports · 2025Article
- End-of-Life Infections and the Dilemma of Emerging Antimicrobial Resistance: A Scoping Review.Infection & chemotherapy · 2025Review
- Attitudes towards antibiotic use in end-of-life care: a nationwide Italian physician survey.Le infezioni in medicina · 2025Article
- Association Between Antibiotic Withdrawal and End-of-Life Comfort in Patients with Advanced Cancer and Suspected Infections: A Multicenter Retrospective Cohort Study.Palliative medicine reports · 2025Article
- Analysis of microbiological tests in patients withholding or withdrawing life-sustaining treatment at the end stage of life in 2 Korean hospitals.Infection control and hospital epidemiology · 2024Article
- Trends of antibiotic use at the end-of-life of cancer and non-cancer decedents: a nationwide population-based longitudinal study (2006-2018).Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Management of Infections in Palliative Care Patients at the End-of-Life and Active Process of Death: A Brazilian Retrospective Study.Palliative medicine reports · 2024Article
- Antibiotics use patterns in end-of-life cancer patients and medical staff's perception of antimicrobial stewardship programs.The Korean journal of internal medicine · 2023Article
- Carbapenem Use in the Last Days of Life: A Nationwide Korean Study.Antibiotics (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundAntimicrobial prescriptions for serious chronic or acute illness nearing its end stages raise concerns about the potential for futile use, adverse events, increased multidrug-resistant organisms, and significant patient and social cost burdens. This study investigated the nationwide situation of how antibiotics are prescribed to patients during the last 14 days of life to guide future actions.
methodsThis nationwide multicenter retrospective cohort study was conducted at 13 hospitals in South Korea from November 1 to December 31, 2018. All decedents were included in the study. Antibiotic use during the last two weeks of their lives was investigated.
resultsA total of 1,201 (88.9%) patients received a median of two antimicrobial agents during the last two weeks of their lives. Carbapenems were prescribed to approximately half of the patients (44.4%) in the highest amount (301.2 days of therapy per 1,000 patient-days). Among the patients receiving antimicrobial agents, 63.6% were inappropriate and only 327 patients (27.2%) were referred by infectious disease specialists. The use of carbapenem (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.13-2.03;
conclusionA considerable number of antimicrobial agents are administered to patients with chronic or acute illnesses nearing their end-of-life, a high proportion of which are prescribed inappropriately. Consultation with an infectious disease specialist, in addition to an antimicrobial stewardship program, may be necessary to induce the optimal use of antibiotics.
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