Evidence map›Paper›PMID 36879824›Full record

ArticleiScience2023

NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis.

Diogo Garcia Valadares, Owen Scott Clay, Yani Chen, Breanna Mary Scorza, Suzanne Louise Cassel, Fayyaz Shiraz Sutterwala, Mary Edythe Wilson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Targeting PANoptosis: a promising therapeutic strategy for ALI/ARDS.Apoptosis : an international journal on programmed cell death · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Diogo Garcia ValadaresDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Owen Scott ClayDepartment of Pediatrics, Division of Pediatric Rheumatology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Yani ChenDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Breanna Mary ScorzaDepartment of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA 52242, USA.
Suzanne Louise CasselDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Fayyaz Shiraz SutterwalaDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Mary Edythe WilsonDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
University of Iowa · USCedars-Sinai Medical Center · USLung Institute · USWake Forest University · US

Funding

TRAINING IN MECHANISMS OF PARASITISMT32AI007511 · NIAID · UNIVERSITY OF IOWA · PI BUTLER, NOAH SULLIVAN, WEBER, MARY · 1996 to 2025
$8.1M
Targeting the NLRP3 inflammasome to limit pathologic sterile inflammationR01AI118719 · NIAID · CEDARS-SINAI MEDICAL CENTER · PI SUTTERWALA, FAYYAZ S. · 2016 to 2020
$2.2M
BLRD VA I01 BX000536BLRD VA I01 BX001983NIAID NIH HHS R01 AI118719NIAID NIH HHS T32 AI007511
6 · The paper itself

Abstract

The NLR protein NLRP12 contributes to innate immunity, but the mechanism remains elusive. Infection of

Indexed as

Cell biologyImmunologyParasitology

Identifiers

PMID36879824
PMCPMC9985045
OpenAlexW4319460447

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.