Evidence map›Paper›PMID 36879812›Full record

ArticleiScience2023

Optical modulation of excitation-contraction coupling in human-induced pluripotent stem cell-derived cardiomyocytes.

Vito Vurro, Beatrice Federici, Carlotta Ronchi, Chiara Florindi, Valentina Sesti, Silvia Crasto, Claudia Maniezzi, Camilla Galli, Maria Rosa Antognazza, Chiara Bertarelli and 3 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Complementary biomolecular coassemblies direct energy transport for cardiac photostimulators.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Intracellular CaFrontiers in physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Vito VurroCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Beatrice FedericiCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Carlotta RonchiCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Chiara FlorindiDepartment of Biotechnology and Biosciences, University of Milan-Bicocca, Building U3 - BIOS, Piazza della Scienza, 2, 20126 Milan, Italy.
Valentina SestiCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Silvia CrastoInstitute of Genetic and Biomedical Research (IRGB), UOS of Milan, National Research Council of Italy, 20138 Milan, Italy.
Claudia ManiezziDepartment of Biotechnology and Biosciences, University of Milan-Bicocca, Building U3 - BIOS, Piazza della Scienza, 2, 20126 Milan, Italy.
Camilla GalliIRCCS-Humanitas Research Hospital, 20089 Rozzano, Italy.
Maria Rosa AntognazzaCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Chiara BertarelliCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Elisa Di PasqualeInstitute of Genetic and Biomedical Research (IRGB), UOS of Milan, National Research Council of Italy, 20138 Milan, Italy.
Guglielmo LanzaniCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Francesco LodolaCenter for Nano Science and Technology @PoliMi, Istituto Italiano di Tecnologia, Via Raffaele Rubattino, 81, 20134 Milan, Italy.
Italian Institute of Technology · ITInstitute of Genetic and Biomedical Research · ITUniversity of Milano-Bicocca · ITIRCCS Humanitas Research Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-genetic photostimulation is a novel and rapidly growing multidisciplinary field that aims to induce light-sensitivity in living systems by exploiting exogeneous phototransducers. Here, we propose an intramembrane photoswitch, based on an azobenzene derivative (Ziapin2), for optical pacing of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The light-mediated stimulation process has been studied by applying several techniques to detect the effect on the cell properties. In particular, we recorded changes in membrane capacitance, in membrane potential (V

Indexed as

Cell biologyMolecular physiologyStem cells research

Identifiers

PMID36879812
PMCPMC9984557
OpenAlexW4318955098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.