ArticleCrystal growth & design2023
Batch Crystallization of Xylitol by Cooling, Evaporative, and Antisolvent Crystallization.
Article in Crystal growth & design, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 23 citations in OpenAlex.
- Intraocular delivery of crystalline sorafenib provides sustained, potent inhibition of wet age-related macular degeneration.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Crystallisation triggered by mass diffusion at a lower local supersaturation.Communications chemistry · 2026Article
- Application and development of ultrasound in industrial crystallization.Ultrasonics sonochemistry · 2024Article
- Influence of Viscosity on Variously Scaled Batch Cooling Crystallization from Aqueous Erythritol, Glucose, Xylitol, and Xylose Solutions.Crystal growth & design · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Four different techniques for xylitol crystallization, namely cooling, evaporative, antisolvent, and combined antisolvent and cooling crystallization, were investigated regarding their influence on the product crystal properties. Various batch times and mixing intensities were studied, and the antisolvent used was ethanol. Real-time monitoring of the count rates of various chord length fractions and distributions using focused beam reflectance measurement was conducted. Several solid characterization methods were used for studying the crystal size and shape, such as scanning electron microscopy and laser diffraction-based crystal size distribution analysis. Crystals ranging in size from 200 to 700 μm were obtained based on the analysis results by laser diffraction. The dynamic viscosity of saturated and undersaturated xylitol solution samples was measured; the density and refraction index were measured to determine the xylitol concentration in the mother liquor. Saturated xylitol solutions were found to have relatively high viscosities up to 129 mPa s in the studied temperature range. Viscosity can have a key role in crystallization kinetics, especially in cooling and evaporative crystallization. Mixing speed had a great influence, mainly on the secondary nucleation mechanism. The addition of ethanol decreased the viscosity, resulting in more uniform crystal shape and better filterability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.