ArticleNano letters2023
Flexible Glass-Based Hybrid Nanofluidic Device to Enable the Active Regulation of Single-Molecule Flows.
Article in Nano letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Beyond the bulk: engineering analytical functions with nanofluidics and nanostructures.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Nanofluidics for Pioneering Synthetic Biology of Bottom-Up Cell-Free Molecular Systems.ACS synthetic biology · 2026Review
- Biosensing With Nanofluidics.Exploration (Beijing, China) · 2026Review
- A review of glass thermal reflow: method, device, and applications.Microsystems & nanoengineering · 2026Review
- Femtoliter Batch Reactors for Nanofluidic Scattering Spectroscopy Analysis of Catalytic Reactions on Single Nanoparticles.Small methods · 2026Article
- The Emergence of Nanofluidics for Single-Biomolecule Manipulation and Sensing.Analytical chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-molecule studies offer deep insights into the essence of chemistry, biology, and materials science. Despite significant advances in single-molecule experiments, the precise regulation of the flow of single small molecules remains a formidable challenge. Herein, we present a flexible glass-based hybrid nanofluidic device that can precisely block, open, and direct the flow of single small molecules in nanochannels. Additionally, this approach allows for real-time tracking of regulated single small molecules in nanofluidic conditions. Therefore, the dynamic behaviors of single small molecules confined in different nanofluidic conditions with varied spatial restrictions are clarified. Our device and approach provide a nanofluidic platform and mechanism that enable single-molecule studies and applications in actively regulated fluidic conditions, thus opening avenues for understanding the original behavior of individual molecules in their natural forms and the development of single-molecule regulated chemical and biological processes in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.