Evidence map›Paper›PMID 36879381›Full record

ArticleBrain and behavior2023

The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.

Rikuya Yoshimura, Tomohiro Miyasaka, Satoru Funamoto, Takashi Saito, Takaomi C Saido, Masaya Ikegawa, Nobuto Kakuda

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rikuya YoshimuraFaculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Tomohiro MiyasakaFaculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Satoru FunamotoFaculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Takashi SaitoLaboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Saitama, Japan.
Masaya IkegawaFaculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
Nobuto KakudaFaculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.ORCID 0000-0001-7011-6891
Doshisha University · JPRIKEN Center for Brain Science · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphology of senile plaques depends on the APP knock-in mice brain fixative. Solid forms of senile plaques were detected in APP knock-in mice after formic acid treatment with Davidson's and Bouin's fluid fixative as the brain of AD patients. Aβ42 was deposited as cored plaques and Aβ38 accumulated around Aβ42.

Indexed as

Alzheimer DiseasePlaque, AmyloidAcetic AcidAnimalsBrainFixativesFormaldehydeMiceMice, TransgenicPicratesAcetic AcidBouin's solutionFixativesFormaldehydePicratesAmyloid β proteinSenile plaque

Identifiers

PMID36879381
PMCPMC10097081
OpenAlexW4323347879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.