Evidence map›Paper›PMID 36879176›Full record

ArticleDigestive diseases and sciences2023

Impact of Bacteria Types on the Clinical Outcomes of Spontaneous Bacterial Peritonitis.

Cameron Furey, Selena Zhou, Joo Hye Park, Andrew Foong, Aneesa Chowdhury, Lillian Dawit, Vivian Lee, Maria Vergara-Lluri, Rosemary She, Jeffrey Kahn and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  4. Review
  5. Article
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  10. Antibiotic treatment in cirrhotic patients.World journal of clinical cases · 2023
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Cameron FureyDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Selena ZhouDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Joo Hye ParkDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Andrew FoongDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Aneesa ChowdhuryDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Lillian DawitDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Vivian LeeDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Maria Vergara-LluriDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Rosemary SheDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Jeffrey KahnDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Jennifer L DodgeDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA.
Takeshi SaitoDivision of Gastrointestinal and Liver Diseases, Department of Medicine, Keck School of Medicine of USC, University of Southern, California2011 Zonal Avenue, HMR 801A, Los Angeles, CA, 90033-9141, USA. saitotak@usc.edu.ORCID http://orcid.org/0000-0002-6165-664X
University of Southern California · US

Funding

USC RESEARCH CENTER FOR LIVER DISEASES: PILOT PROGRAMSP30DK048522 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAPLOWITZ, NEIL · 1995 to 2020
$21.8M
NIDDK NIH HHS P30 DK048522
6 · The paper itself

Abstract

BACKGROUND AND

aimsCirrhotic patients presenting with spontaneous bacterial peritonitis (SBP) have elevated risk of short-term mortality. While high Model for End-Stage Liver Disease-Sodium score (MELD-Na) and ascites culture yielding multi-drug resistance (MDR) bacteria are well established risk factors for further aggravating mortality, the impact of individual, causative microorganisms and their respective pathogenesis have not been previously investigated.

methodsThis is a retrospective study of 267 cirrhotic patients at two tertiary care hospitals undergoing paracentesis from January 2015 to January 2021 who presented with ascitic PMN count > 250 cells

resultsOf 267 patients with SBP, the ascitic culture yielded causative microorganism in 88 cases [median age 57 years (IQR 52-64)]; 68% male; median MELD-Na 29 (IQR 23-35). The microbes isolated were E. coli (33%), Streptococcus (15%), Klebsiella (13%), Enterococcus (13%), Staphylococcus (9%) and others (18%); 41% were MDR. Cumulative incidence of SBP progression within 1-month was 91% (95% CI 67-100) for Klebsiella, 59% (95% CI 42-76) for E. coli, and 16% (95% CI 4-51) for Streptococcus. After adjusting for MELD-Na and MDR, risk of SBP progression remained elevated for Klebsiella (HR 2.07; 95% CI 0.98-4.24; p-value = 0.06) and decreased for Streptococcus (HR 0.28; 95% CI 0.06-1.21; p-value = 0.09) compared to all other bacteria.

conclusionOur study found Klebsiella-associated SBP had worse clinical outcomes while Streptococcus-associated SBP had the most favorable outcomes after accounting for MDR and MELD-Na. Thus, identification of the causative microorganism is crucial not only for optimizing the treatment but for prognostication.

Indexed as

Bacterial InfectionsEnd Stage Liver DiseasePeritonitisAscitesAscitic FluidEscherichia coliFemaleHumansLiver CirrhosisMaleMiddle AgedRetrospective StudiesSeverity of Illness IndexKlebsiella pneumoniaLiver transplantationMortalitySpontaneous bacterial peritonitisStreptococcus

Identifiers

PMID36879176
PMCPMC10133085
OpenAlexW4323304722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.