ArticleNature communications2023
Zebrafish pigment cells develop directly from persistent highly multipotent progenitors.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 70 citations in OpenAlex.
- Article
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- The role of m6A modification in spermatogenic dysfunction.Molecular biology reports · 2026Review
- Control Strategies in Guanine Biocrystallization.Angewandte Chemie (International ed. in English) · 2026Review
- Lysosome-related organelles orchestrate guanine crystal formation in pigment cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Loss of MITF activity leads to emergent cell states from the melanocyte stem cell lineage.bioRxiv : the preprint server for biology · 2026Article
- Single-Nucleus Transcriptional Profiling Revealed Cell Diversity and Albino Mutation Mechanism in the Skin ofInternational journal of molecular sciences · 2026Article
- Linking tissue morphology and tissue healing in a cell-fate model.Frontiers in cell and developmental biology · 2026Article
- The syntenic long non-coding RNA DANCR is an essential regulator of zebrafish development and a human melanoma oncogene.PLoS genetics · 2025Article
- Insertion of an invading retrovirus regulates a novel color trait in swordtail fish.bioRxiv : the preprint server for biology · 2025Article
- Specialized molecular pathways drive the formation of light-scattering assemblies in leucophores.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genetic control over biogenic crystal morphogenesis in zebrafish.Nature chemical biology · 2025Article
- Melanocyte lineage dynamics in development, growth and disease.Development (Cambridge, England) · 2024Review
- Keratinocytes drive the epithelial hyperplasia key to sea lice resistance in coho salmon.BMC biology · 2024Article
- Oscillatory differentiation dynamics fundamentally restricts the resolution of pseudotime reconstruction algorithms.Journal of the Royal Society, Interface · 2024Article
- High frequency of melanoma inTheranostics · 2024Article
- A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish.Development (Cambridge, England) · 2023Article
- Maintenance of pluripotency-like signature in the entire ectoderm leads to neural crest stem cell potential.Nature communications · 2023Article
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Corrections and comments
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Authors and funding
15 authors at 7 institutions in 5 countries.
Funding
Abstract
Neural crest cells are highly multipotent stem cells, but it remains unclear how their fate restriction to specific fates occurs. The direct fate restriction model hypothesises that migrating cells maintain full multipotency, whilst progressive fate restriction envisages fully multipotent cells transitioning to partially-restricted intermediates before committing to individual fates. Using zebrafish pigment cell development as a model, we show applying NanoString hybridization single cell transcriptional profiling and RNAscope in situ hybridization that neural crest cells retain broad multipotency throughout migration and even in post-migratory cells in vivo, with no evidence for partially-restricted intermediates. We find that leukocyte tyrosine kinase early expression marks a multipotent stage, with signalling driving iridophore differentiation through repression of fate-specific transcription factors for other fates. We reconcile the direct and progressive fate restriction models by proposing that pigment cell development occurs directly, but dynamically, from a highly multipotent state, consistent with our recently-proposed Cyclical Fate Restriction model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.