ArticleNeurology2023
Characteristics and Clinical Implication of White Matter Lesions in Patients With Adult Moyamoya Disease.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Unraveling the links between intracranial artery stenosis, cerebral perfusion, and white matter hyperintensity in moyamoya disease.European radiology · 2026Article
- Regional disparities in cerebral perfusion and brain tissue microstructure damage in adult patients with Moyamoya syndrome.Scientific reports · 2025Article
- Cognitive characteristics and ischemic prognosis of quantitative white matter hyperintensities in adult moyamoya disease.Communications medicine · 2025Article
- Pathophysiological link between carotid atherosclerosis and cerebral white matter lesions.Scientific reports · 2025Article
- Whole-brain volumetric analysis in adult Moyamoya patients reveals significant atrophy compared to healthy controls.Brain communications · 2025Article
- White matter hyperintensities in cholinergic pathways correlates of cognitive impairment in moyamoya disease.European radiology · 2024Article
- Resolution of white matter hyperintensity after surgical revascularization in moyamoya disease - A report of three cases.Surgical neurology international · 2024Article
- Characteristics and Clinical Implication of White Matter Lesions in Patients With Adult Moyamoya Disease.Neurology · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesWhite matter hyperintensities (WMHs) are reportedly increased in moyamoya disease (MMD); however, their clinical importance is not well-established owing to their pathophysiologic heterogeneity by distribution. This study aimed to evaluate the burden and pattern of WMHs and its clinical implications in the MMD trajectory.
methodsAdult patients with MMD without significant structural lesions were 1:1 propensity score-matched with healthy controls for sex and vascular risk factors. The total, periventricular, and subcortical WMH volumes were segmented and quantified fully automatically. WMH volumes were detrended by age and compared between the 2 groups. MMD severity based on Suzuki stage and future ischemic events were assessed for their association with WMH volumes.
resultsA total of 161 pairs of patients with MMD and controls were analyzed. MMD significantly correlated with increased total WMH volume (B [standard error], 0.126 [0.030]; DISCUSSION: Periventricular WMHs, but not subcortical WMHs, may represent the main pathophysiology of MMD. Periventricular WMHs may be used as a marker for ischemic vulnerability in patients with MMD.
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