Evidence map›Paper›PMID 36878486›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2023

Attenuated cardiac autonomic function in humans with high-affinity hemoglobin and compensatory polycythemia.

Wyatt W Pruter, Stephen A Klassen, Paolo B Dominelli, Chad C Wiggins, Jonathon W Senefeld, Tuhin K Roy, Michael J Joyner, Sarah E Baker

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wyatt W PruterDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4647-0476
Stephen A KlassenDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4560-8728
Paolo B DominelliDepartment of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.ORCID 0000-0001-5575-4043
Chad C WigginsDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-6458-0142
Jonathon W SenefeldDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-8116-3538
Tuhin K RoyDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-8182-7629
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7135-7643
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-9647-7660
Mayo Clinic · USUniversity of Waterloo · CA

Funding

DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
Hot Flashes and Neurovascular Function in WomenK01HL148144 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2021 to 2025
$867k
Skeletal muscle performance and cellular adaptations to high hemoglobin-oxygen affinityF32HL154320 · NHLBI · MAYO CLINIC ROCHESTER · PI SENEFELD, JONATHON · 2020 to 2021
$117k
NHLBI NIH HHS F32 HL154320NHLBI NIH HHS K01 HL148144NHLBI NIH HHS R35 HL139854NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

During hypoxic exposure, humans with high-affinity hemoglobin (and compensatory polycythemia) have blunted increases in heart rate compared with healthy humans with typical oxyhemoglobin dissociation curves. This response may be associated with altered autonomic control of heart rate. Our hypothesis-generating study aimed to investigate cardiac baroreflex sensitivity and heart rate variability among nine humans with high-affinity hemoglobin [6 females, O

Indexed as

PolycythemiaArterial PressureAutonomic Nervous SystemBaroreflexBlood PressureFemaleHeartHeart RateHumansHypoxiabaroreflex sensitivityblood pressure regulationcardiovascularheart rate variabilityhypoxia

Identifiers

PMID36878486
PMCPMC10085552
OpenAlexW4323305406

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.