ArticleNeuroendocrinology2023
Estradiol Enhances the Development of Addiction-Like Features in a Female Rat Model of Opioid Use Disorder.
Article in Neuroendocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Ovarian Hormones and Addictive Behaviour Vulnerability: Insights From Preclinical Studies.Addiction biology · 2025Pooled it
- Can the incentive-sensitization theory of addiction incorporate addiction to opioid drugs?Psychopharmacology · 2026Review
- Sex chromosome genes contribute to cocaine vulnerability in a strain-dependent manner.Research square · 2026Article
- Fentanyl reinforcement history has sex-specific effects on multi-step decision-making.Neuropharmacology · 2026Article
- AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Compliance and Satisfaction With a Protocol for Identifying Novel Targets to Support Postpartum Opioid Use Disorder Recovery: Prospective Cohort Study.JMIR formative research · 2025Article
- Proteomic analysis of plasma proteins during fentanyl withdrawal in ovariectomized female rats with and without estradiol.Journal of neuroendocrinology · 2025Article
- Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains.Biological psychiatry global open science · 2025Article
- Sex and estradiol effects in the rodent dorsal striatum.The European journal of neuroscience · 2024Review
- Sex Differences in the Development of an Opioid Addiction-Like Phenotype: A Focus on the Telescoping Effect.Biological psychiatry global open science · 2024Article
- Estrogen receptor beta signaling enhances extinction memory recall for heroin-conditioned cues in a sex- and region-specific manner.Translational psychiatry · 2024Article
- The effects of gonadal hormones on heroin Self-Administration in male gonadectomized rats.Psychopharmacology · 2024Article
- Sex Chromosome Complement and Estradiol Modify Cocaine Self-Administration Behaviors in Male Mice.Neuroendocrinology · 2023Article
- Role of Hormones in Substance Use Disorders.Neuroendocrinology · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionWomen are more vulnerable than men in many aspects of opioid use disorder (OUD); a major theory of sex differences in substance use disorders is that these differences are due to ovarian hormones with estradiol enhancing vulnerability in females. However, most of this evidence is for psychostimulants and alcohol; evidence with opioids is sparse. Thus, the goal of this study was to determine the impact of estradiol on vulnerability in females in a rat model of OUD.
methodFollowing self-administration training, ovariectomized (OVX) females with (E) or without (V) estradiol replacement were given extended (24 h/day), intermittent access (2, 5-min trials/h) to fentanyl for 10 days. Then, the development of three key features of OUD were assessed, including physical dependence, defined by the magnitude and time course of weight loss during withdrawal; an enhanced motivation for fentanyl, assessed using a progressive-ratio schedule; and relapse vulnerability, assessed using an extinction/cue-induced reinstatement procedure. These later two characteristics were examined following 14 days of withdrawal when the phenotypes are known to be highly expressed.
resultsOVX+E females self-administered markedly higher levels of fentanyl under extended, intermittent-access conditions and showed a longer time course of physical dependence, a greater increase in motivation for fentanyl, and an enhanced sensitivity to the reinstating effects of fentanyl-associated cues compared to OVX+V rats. Severe health complications were also observed in OVX+E, but not OVX+V females, during withdrawal.
conclusionThese results indicate that, as with findings with psychostimulants and alcohol, estradiol enhances vulnerability in females to developing opioid addiction-like features and serious opioid-related health complications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.