Evidence map›Paper›PMID 36877849›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide receptor family members.

Baba M Yussif, Cole V Blasing, James W Checco

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Heterochiral peptides reshaping class B1 GPCR agonism.Trends in pharmacological sciences · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. A novel series of metazoan L/D peptide isomerases.The Journal of biological chemistry · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Baba M YussifDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588.ORCID 0000-0002-4540-0388
Cole V BlasingDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588.ORCID 0000-0002-6993-9601
James W CheccoDepartment of Chemistry, University of Nebraska-Lincoln, Lincoln, NE 68588.ORCID 0000-0003-1165-6163
University of Nebraska–Lincoln · US

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
NIGMS NIH HHS P20 GM113126
6 · The paper itself

Abstract

The l- to d-amino acid residue isomerization of neuropeptides is an understudied post-translational modification found in animals across several phyla. Despite its physiological importance, little information is available regarding the impact of endogenous peptide isomerization on receptor recognition and activation. As a result, the full roles peptide isomerization play in biology are not well understood. Here, we identify that the

Indexed as

Amino AcidsReceptors, NeuropeptideAnimalsAplysiaIsomerismLigandsPhenylalanineAmino AcidsLigandsPhenylalanineReceptors, Neuropeptidecell-cell signalingDAACPGPCRisomerizationneuropeptide

Identifiers

PMID36877849
PMCPMC10089201
OpenAlexW4323306596

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.